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Title: Influence of heat treatment on spray-dried mixtures of Amioca (R) starch and Carbopol (R) 974P used as carriers for nasal drug delivery
Authors: Coucke, D.
Pringels, E.
Foreman, P.
Remon, J. P.
Vervaet, C.
Issue Date: 2009
Abstract: A mucoadhesive spray-dried starch/poly(acrylic acid) powder underwent different heat treatments in order to induce cross-linking between the functional groups of starch (Amioca (R)) and poly(acrylic acid) (Carbopol (R) 974P). After heat treatment the water-absorbing capacity, viscosity and elasticity of the mucoadhesive powder increased. NMR analysis in combination with FT-IR indicated that heat treatment induced a low degree of cross-linking between the polymers. Nasal administration of Amioca (R)/Carbopol (R) 974P powders without heat treatment resulted in an absolute bioavailability in rabbits of 8.2 +/- 3.0% for insulin. Due to the difference in water-absorbing capacity (which opened the tight junctions of the nasal mucosa), elasticity and plasticity (which reduced mucociliairy clearance and prolonged residence time) heat treatment at 120 degrees C improved the bioavailability: 26.4 +/- 21.9, 36.5 +/- 11.0 and 19.3 +/- 17.3% after heat treatment during 30 min, 1 h and 4 h, respectively. Heat treatment at 60 degrees C was less efficient. This study demonstrated that the nasal insulin absorption improved via heat treatment of the Amioca (R)/Carbopol (R) 974P powder (prior to the addition of insulin). The bioavailability-enhancing effect of a 1 h heat treatment at 120 degrees C was confirmed using the same polymer matrix in combination with different drugs (salmon calcitonin, human growth hormone and metoprolol tartrate). (C) 2009 Elsevier B.V. All rights reserved.
Notes: [Coucke, D.; Pringels, E.; Remon, J. P.; Vervaet, C.] Univ Ghent, Pharmaceut Technol Lab, B-9000 Ghent, Belgium. [Adriaensens, P.; Carleer, R.] Hasselt Univ, Div Chem, Inst Mat Res IMO, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/9917
DOI: 10.1016/j.ijpharm.2009.05.041
ISI #: 000269163600007
ISSN: 0378-5173
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

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