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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9912

Title: Regulation of fatty acid oxidation in chicken (Gallus gallus): Interactions between genotype and diet composition
Authors: Collin, A.
SWENNEN, Quirine
Skiba-Cassy, S.
Buyse, J.
Chartrin, P.
Le Bihan-Duval, E.
Crochet, S.
Duclos, M. J.
Joubert, R.
Decuypere, E.
Tesseraud, S.
Issue Date: 2009
Publisher: ELSEVIER SCIENCE INC
Citation: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 153(2). p. 171-177
Abstract: To explore the mechanisms leading to excessive adiposity in chicken, we investigated the regulation of fatty acid oxidation depending on genotype-related body fatness and diet composition. mRNA expression and/or activity of proteins involved in mitochondrial energy metabolism were measured in liver and gastrocnemius muscle of genetically lean or fat chickens reared on a low-fat/high-protein diet or an isoenergetic high-fat/low-protein diet (HF/LP). Muscle expressions of the muscle isoform of carnitine-paimitoyltransferase 1 (M-CPT1) and PPAR beta/delta were higher in fat than in lean chickens. This was also observed in liver, although only with the HF/LP diet for M-CPTI. This could stimulate mitochondrial fatty add oxidation in fat chickens. Up-regulations of liver and muscle CPT-1 hepatic isoform, and muscle cytochrome-c-oxidase mRNA expressions, and of beta-hydroxyacyl-CoA-dehydrogenase activities suggest higher fatty acid utilization with the HF/LP diet. PPAR beta/delta and PGC-1 alpha could control fatty acid oxidation in muscle and liver, respectively. Regulation of avian uncoupling protein (avUCP) mRNA was tissue-dependent. Predominantly expressed in muscle, it was stimulated in fat and in HF/LP-fed chickens, where it could be associated to the special need in muscle anti-oxidant pathways of fatter animals. In liver it was lower in fat than in lean chickens, and its potential function remains to be clarified. (C) 2009 Elsevier Inc. All rights reserved.
Notes: [Collin, A.; Chartrin, P.; Le Bihan-Duval, E.; Crochet, S.; Duclos, M. J.; Joubert, R.; Tesseraud, S.] INRA, Rech Avicoles UR83, F-37380 Nouzilly, France. [Swennen, Q.; Buyse, J.; Decuypere, E.] Katholieke Univ Leuven, Lab Livestock Physiol Immunol & Genet Domest Anim, Dept Biosyst, B-3001 Louvain, Belgium. [Swennen, Q.] Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. [Skiba-Cassy, S.] INRA, UMR Nutr 1067, F-64310 St Pee Sur Nivelle, France.
URI: http://hdl.handle.net/1942/9912
DOI: 10.1016/j.cbpb.2009.02.012
ISI #: 000269764800006
ISSN: 1096-4959
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

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