Document Server@UHasselt >
Research publications >
Please use this identifier to cite or link to this item:
|Title: ||The expression of the Goodpasture antigen-binding protein (ceramide transporter) in adult rat brain|
|Authors: ||Mencarelli, Chiara|
Van den Broeck, Joost
Hopkins, David A.
DE BAETS, Marc
Steinbusch, Harry W.
|Issue Date: ||2009|
|Publisher: ||ELSEVIER SCIENCE BV|
|Citation: ||JOURNAL OF CHEMICAL NEUROANATOMY, 38(2). p. 97-105|
|Abstract: ||The Goodpasture antigen-binding protein (GPBP) plays a critical role in brain development. Knockdown of GPBP leads to loss of myelinated tracts in the central nervous system and to extensive apoptosis in the brain during early embryogenesis. GPBP was initially identified as a protein associated with the autoantigen in Goodpasture autoimmune syndrome, where it was shown to be a kinase that regulates type IV collagen organization. GPBP isoforms bind and transport ceramide from the endoplasmic reticulum to the Golgi apparatus and are therefore also known as ceramide transporters (CERT). Ceramide dysregulation is involved in autoimmunity and neurodegenerative disorders. In order to analyze the possible role of GPBP in neuroinflammation and neurodegeneration we studied the basal GPBP expression in normal rat brain. High levels of immunoreactivity were detected in neurons of the cerebral cortex, hippocampal formation, the basal ganglia, the olfactory bulb and nuclei of the thalamus, the hypothalamus and the septal area. Lower expression levels of GPBP were observed widely throughout the brain, suggesting that GPBP plays an important role in central nervous system neuron function. (C) 2009 Elsevier B.V. All rights reserved.|
|Notes: ||[Mencarelli, Chiara; Hammels, Caroline; Van den Broeck, Joost; Losen, Mario; Steinbusch, Hellen; De Baets, Marc H.; Steinbusch, Harry W.; Martinez-Martinez, Pilar] Univ Maastricht, Dept Neurosci, Sch Mental Hlth & Neurosci, NL-6200 MD Maastricht, Netherlands. [Revert, Francisco; Saus, Juan] Univ Valencia, Ctr Invest Principe Felipe, Valencia, Spain. [Revert, Francisco; Saus, Juan] Univ Valencia, Dept Bioquim & Biol Mol, Valencia, Spain. [Hopkins, David A.] Dalhousie Univ, Dept Anat & Neurobiol, Halifax, NS, Canada. [De Baets, Marc H.] Hasselt Univ, Biomed Res Inst BIOMED, Neuroimmunol Grp, Diepenbeek, Belgium.|
|ISI #: ||000269734900002|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2010|
|Appears in Collections: ||Research publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.