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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9899

Title: The expression of the Goodpasture antigen-binding protein (ceramide transporter) in adult rat brain
Authors: Mencarelli, Chiara
Hammels, Caroline
Van den Broeck, Joost
Losen, Mario
Steinbusch, Hellen
Revert, Francisco
Saus, Juan
Hopkins, David A.
Steinbusch, Harry W.
Martinez-Martinez, Pilar
Issue Date: 2009
Citation: JOURNAL OF CHEMICAL NEUROANATOMY, 38(2). p. 97-105
Abstract: The Goodpasture antigen-binding protein (GPBP) plays a critical role in brain development. Knockdown of GPBP leads to loss of myelinated tracts in the central nervous system and to extensive apoptosis in the brain during early embryogenesis. GPBP was initially identified as a protein associated with the autoantigen in Goodpasture autoimmune syndrome, where it was shown to be a kinase that regulates type IV collagen organization. GPBP isoforms bind and transport ceramide from the endoplasmic reticulum to the Golgi apparatus and are therefore also known as ceramide transporters (CERT). Ceramide dysregulation is involved in autoimmunity and neurodegenerative disorders. In order to analyze the possible role of GPBP in neuroinflammation and neurodegeneration we studied the basal GPBP expression in normal rat brain. High levels of immunoreactivity were detected in neurons of the cerebral cortex, hippocampal formation, the basal ganglia, the olfactory bulb and nuclei of the thalamus, the hypothalamus and the septal area. Lower expression levels of GPBP were observed widely throughout the brain, suggesting that GPBP plays an important role in central nervous system neuron function. (C) 2009 Elsevier B.V. All rights reserved.
Notes: [Mencarelli, Chiara; Hammels, Caroline; Van den Broeck, Joost; Losen, Mario; Steinbusch, Hellen; De Baets, Marc H.; Steinbusch, Harry W.; Martinez-Martinez, Pilar] Univ Maastricht, Dept Neurosci, Sch Mental Hlth & Neurosci, NL-6200 MD Maastricht, Netherlands. [Revert, Francisco; Saus, Juan] Univ Valencia, Ctr Invest Principe Felipe, Valencia, Spain. [Revert, Francisco; Saus, Juan] Univ Valencia, Dept Bioquim & Biol Mol, Valencia, Spain. [Hopkins, David A.] Dalhousie Univ, Dept Anat & Neurobiol, Halifax, NS, Canada. [De Baets, Marc H.] Hasselt Univ, Biomed Res Inst BIOMED, Neuroimmunol Grp, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/9899
DOI: 10.1016/j.jchemneu.2009.06.005
ISI #: 000269734900002
ISSN: 0891-0618
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

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