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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9847

Title: Immunosuppression of experimental autoimmune myasthenia gravis by mycophenolate mofetil
Authors: Janssen, Sofie P. M.
Phernambucq, Marko
Martinez-Martinez, Pilar
DE BAETS, Marc
Losen, Mario
Issue Date: 2008
Publisher: ELSEVIER SCIENCE BV
Citation: JOURNAL OF NEUROIMMUNOLOGY, 201. p. 111-120
Abstract: Currently used non-specific immunosuppresive drugs often require intervention in myasthenia gravis (MG) and clinical improvement varies widely. To analyze the therapeutic effect of mycophenolate mofetil (MMF) in experimental autoimmune MG (EAMG), rats were immunized with acetylcholine receptors (AChRs) and subsequently treated with MMF or vehicle. MMF treatment resulted in a significant suppression of anti-rat AChR antibody titers. Interestingly, no abnormalities of neuromuscular transmission and adverse side effects were detected in MMF-treated EAMG animals. Moreover, anti-rat AChR antibody titers correlated to an improvement of clinical outcome. In conclusion, our data suggest that MMF acts as a potent immunosuppressant drug in EAMG. (C) 2008 Elsevier B.V All rights reserved.
Notes: [Janssen, Sofie P. M.; Phernambucq, Marko; Martinez-Martinez, Pilar; De Baets, Marc H.; Losen, Mario] Maastricht Univ, Fac Hlth Med & Life Sci, Sch Mental Hlth & Neurosci, Dept Neurosci, NL-6200 MD Maastricht, Netherlands. [De Baets, Marc H.] Hasselt Univ, Biomed Res Inst BIOMED, Neuroimmunol Grp, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/9847
DOI: 10.1016/j.jneuroim.2008.05.029
ISI #: 000260294800018
ISSN: 0165-5728
Category: A1
Type: Journal Contribution
Validation: ecoom, 2009
Appears in Collections: Research publications

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