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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9809

Title: Local LIF Production in the CNS Limits Autoimmune Demyelination
Authors: SLAETS, Leen
HENDRIKS, Jerome
Van den Haute, Chris
Baekelandt, Veerle
STINISSEN, Piet
HELLINGS, Niels
Issue Date: 2009
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation: CLINICAL IMMUNOLOGY, 131. p. S123-S124
Abstract: Multiple sclerosis is a demyelinating disease of the central nervous system (CNS) with an inflammatory and a neurodegenerative component. The neuropoietic cytokine leukemia inhibitory factor (LIF) is expressed in MS lesions, but its effect on lesion development is far from understood. LIF is suggested to be an interesting candidate for MS therapy, as it has neuroprotecive properties and may also promote survival of myelinating oligodendrocytes. However, therapeutic administration of LIF is complicated by its limited ability to cross the blood-brain barrier and its pleiotropic actions outside the CNS. To circumvent these problems, we used lentiviral vectors to achieve a stable expression and secretion of LIF in the CNS of adult mice. Gene therapeutic expression of LIF in the CNS significantly reduced immune-mediated demyelination and ameliorated EAE symptoms with enhanced efficacy compared to systemic treatment. These findings demonstrate that local LIF production is a promising therapeutic option to limit lesion progression in neuroinflammatory disease.
Notes: [Slaets, Helena; Hendriks, Jerome; Stinissen, P.; Hellings, Niels] Hasselt Univ, Diepenbeek, Belgium. [Slaets, Helena; Hendriks, Jerome; Stinissen, P.; Hellings, Niels] Transnatl Univ Limburg, Diepenbeek, Belgium. [Van den Haute, Chris; Baekelandt, Veerle] Katholieke Univ Leuven, Louvain, Belgium.
URI: http://hdl.handle.net/1942/9809
DOI: 10.1016/j.clim.2009.03.365
ISI #: 000266342300357
ISSN: 1521-6616
Category: M
Type: Journal Contribution
Appears in Collections: Research publications

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