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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9807

Title: Efficacy and safety of direct and frontal macrobiopsies in breast cancer
Authors: Cornelis, Ann
Verjans, Marcel
Van den Bosch, Thierry
Wouters, Katrien
Van Robaeys, Johan
JANSSENS, Jaak
Issue Date: 2009
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Citation: EUROPEAN JOURNAL OF CANCER PREVENTION, 18(4). p. 280-284
Abstract: Recent innovations in tissue acquisition from the human breast have led to the development of unique direct frontal systems. We intend to evaluate efficacy and safety in a multicenter clinical study. Efficacy was considered optimal if the diagnosis by transcutaneous biopsy was identical to the surgical specimen in case of malignancy or in line with clinical follow-up when benign. One hundred and seventy-three women (aged 22-95 years) with a suspect lesion in the breast were eligible for transdermal biopsy. One hundred and seventeen biopsies were performed with the Spirotome and 56 with the Coramate under radiological or ultrasound guidance. Sample quality was evaluated by comparing the pathology results of the samples with definitive pathology at subsequent surgery or follow-up in case of benign lesions. An average of 1.66 biopsies per procedure were obtained. All patients had sufficient sample size (up to 5 mm diameter/20 mm length) to make a reliable diagnosis. The average length was 1.39 cm and the average diameter 3.72 mm. There were three false-negative diagnoses, leaving a correct diagnosis in 170 patients. None of the patients suffered from a serious complication, and the procedure was generally well tolerated. The new direct frontal transdermal tissue acquisition approach gives adequate diagnostic results through high-quality tissue samples. No major patient discomfort was noted. European Journal of Cancer Prevention 18:280-284 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
Notes: [Cornelis, Ann; Verjans, Marcel; Van den Bosch, Thierry] H Hartziekenhuis, Dept Pathol & Gynaecol, Tienen, Belgium. [Wouters, Katrien] Salvatorziekenhuis, Dept Pathol, Hasselt, Belgium. [Van Robaeys, Johan] Ziekenhuis Oost Limburg, Dept Pathol, Genk, Belgium. [Janssens, Jaak Ph.] Univ Hasselt, Limburg Univ Ctr, Hasselt, Limburg, Belgium.
URI: http://hdl.handle.net/1942/9807
DOI: 10.1097/CEJ.0b013e328329d885
ISI #: 000266575700003
ISSN: 0959-8278
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

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