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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9790

Title: Spine radiographs to improve the identification of women at high risk for fractures
Authors: Netelenbos, J. C.
Lems, W. F.
GEUSENS, Piet
Verhaar, H. J.
Boermans, A. J. M.
Boomsma, M. M.
Mulder, P. G. H.
Papapoulos, S. E.
Issue Date: 2009
Publisher: SPRINGER LONDON LTD
Citation: OSTEOPOROSIS INTERNATIONAL, 20(8). p. 1347-1352
Abstract: In women older than 60 years with clinical risk factors for osteoporosis but without osteoporosis based on bone mineral density (T-score a parts per thousand yenaEuro parts per thousand a'2.5), a systematic survey with X-rays of the spine identified previously unknown vertebral deformities in 21% of women. This study determines the prevalence of vertebral deformities in elderly women with clinical risk factors for osteoporosis but with BMD values above the threshold for osteoporosis (T-score a parts per thousand yenaEuro parts per thousand a'2.5). Bisphosphonate na < ve women older than 60 years attending 35 general practices in the Netherlands with a parts per thousand yen2 clinical risk factors for osteoporosis were invited for BMD measurement (DXA). In women with T-score a parts per thousand yenaEuro parts per thousand a'2.5 at both spine and the hips, lateral radiographs of the thoracic and lumbar spine were performed. Of 631 women with a DXA measurement, 187 (30%) had osteoporosis (T-score < -2.5 at the spine or the hip). Of the remaining 444 women with T-score a parts per thousand yenaEuro parts per thousand a'2.5 at both spine and hip, 387 had additional spine radiographs, of whom 80 (21%) had at least one vertebral deformity. In elderly women with clinical risk factors for osteoporosis but BMD T-score a parts per thousand yenaEuro parts per thousand a'2.5, addition of spine radiographs identified vertebral deformities in 21% (95% CI: 17-25). Since these women are at risk of future fractures, antiosteoporotic treatment should be considered.
Notes: [Netelenbos, J. C.] Vrije Univ Amsterdam, Med Ctr, Dept Endocrinol, NL-1081 HV Amsterdam, Netherlands. [Lems, W. F.] Vrije Univ Amsterdam, Med Ctr, Dept Rheumatol, NL-1081 HV Amsterdam, Netherlands. [Geusens, P. P.] Univ Hosp, Dept Internal Med Rheumatol, Maastricht, Netherlands. [Geusens, P. P.] Univ Hasselt, Hasselt, Belgium. [Verhaar, H. J.] Univ Med Ctr, Dept Geriatr Med, Mobil Lab, Utrecht, Netherlands. [Boomsma, M. M.] GlaxoSmithKline Inc, Dept Med, Zeist, Netherlands. [Mulder, P. G. H.] Erasmus Univ, Med Ctr, Rotterdam, Netherlands. [Papapoulos, S. E.] Univ Med Ctr, Dept Endocrinol & Metab Dis, Leiden, Netherlands.
URI: http://hdl.handle.net/1942/9790
DOI: 10.1007/s00198-008-0801-1
ISI #: 000267915200009
ISSN: 0937-941X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

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