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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9788

Title: Determinants of polychlorinated aromatic hydrocarbons in serum in three age classes-Methodological implications for human biomonitoring
Authors: Den Hond, Elly
Govarts, Eva.
BRUCKERS, Liesbeth
Schoeters, Greet
Issue Date: 2009
Citation: ENVIRONMENTAL RESEARCH, 109(4). p. 495-502
Abstract: Human biomonitoring provides an integrated measure for individual exposure to environmental pollutants. Better insight in inter-individual variability of biomarkers of exposure may help in the interpretation of biomonitoring studies. The aim was to study the impact of outliers, determine the optimal unit for fat-soluble biomarkers in serum and quantify the major determinants for biomarkers of exposure to polychlorinated aromatic hydrocarbons (PCAHs) in three age groups. Data were obtained from the Flemish Environment and Health Study (2002-2006). Marker PCBs (sum of 138,153,180), hexachlorobenzene (HCB) and p,p'-DDE were measured in cord blood samples of 1196 newborns, in serum samples of 1679 adolescents (14-15 years) and 1583 adults (50-65 years). Exclusion of influential outliers in multiple linear regression models lead to models that are better applicable to the general population. In terms of adjusted R 2, the regression model with the pollutant expressed in volume-based units and blood fat as a separate independent variable was superior compared to models with other units. We found highly consistent relationships between the serum concentration of PCAHs and blood fat, age, changes in body weight, animal fat in the diet, local vegetable consumption (HCB and p,p'-DDE only) and being breastfed as a baby (in adolescents only). The impact of sex and BMI differed toy age. For biomarkers of persistent pollutants that reflect long-term exposure, the relation between the covariates and the biomarkers can be well quantified. (C) 2009 Elsevier Inc. All rights reserved.
Notes: [Den Hond, Elly; Govarts, Eva; Schoeters, Greet] Flemish Inst Technol Res VITO, B-2400 Mol, Belgium. [Bruckers, Liesbeth] Univ Hasselt, Interuniv Biostat & Stat Bioinformat, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/9788
DOI: 10.1016/j.envres.2009.02.007
ISI #: 000265897700015
ISSN: 0013-9351
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

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