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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9693

Title: Progressive vertebral deformities despite unchanged bone mineral density in patients with sarcoidosis: a 4-year follow-up study
Authors: Heijckmann, A. C.
Drent, M.
Dumitrescu, B.
De Vries, J.
Kruseman, A. C. Nieuwenhuijzen
Wolffenbuttel, B. H. R.
Huijberts, M. S. P.
Issue Date: 2008
Citation: OSTEOPOROSIS INTERNATIONAL, 19(6). p. 839-847
Abstract: To evaluate the incidence of new and/or progressive vertebral deformities and changes in bone mineral density, we re-examined 66 patients with sarcoidosis after a follow-up period of four years. In 17 subjects (26%) new and/or progressive vertebral deformities were found, though BMD did not change significantly. Introduction Previous studies from our group have shown that morphometric vertebral deformities suggestive of fractures can be found in 20% of patients with sarcoidosis, despite a normal bone mineral density (BMD). The aim of this study was to determine the incidence of new and/or progressive vertebral deformities and the evolution of BMD during the course of this disease. Methods BMD of the hip (DXA) and vertebral fracture assessment (VFA) with lateral single energy densitometry was performed at baseline and after 45 months in 66 patients with sarcoidosis. Potential predictors of new/progressive vertebral deformities were assessed using logistic regression analysis. Results The BMD of the total group was unchanged after follow-up. The prevalence of vertebral deformities increased from 20 to 32% (p < 0.05); in 17 subjects (26%) new or progressive vertebral deformities were diagnosed. A lower T-score of the femoral neck [(OR = 2.5 (CI: 1.0-5.9), p < 0.05)] and mother with a hip fracture [(OR= 14.1 (CI: 1.4-142.6), p < 0.05)] were independent predictors of new/progressive deformities. Conclusions In subjects with sarcoidosis the number of vertebral deformities increases in the course of this disease, despite unchanged BMD. The combination of low normal BMD and family history of fragility fractures confers an increased risk of the incidence of these deformities.
Notes: [Heijckmann, A. C.] Hosp Bernhoven Veghel Oss, Dept Internal Med, NL-5460 DA Veghel, Netherlands. [Heijckmann, A. C.; Kruseman, A. C. Nieuwenhuijzen; Huijberts, M. S. P.] Univ Hosp Maastricht, Dept Internal Med, Div Endocrinol, Maastricht, Netherlands. [Drent, M.] Univ Hosp Maastricht, Dept Resp Med, Maastricht, Netherlands. [Drent, M.; De Vries, J.; Geusens, P.] Univ Hosp Maastricht, Sarcoidosis Management Team, Maastricht, Netherlands. [De Vries, J.] Tilburg Univ, Dept Psychol & Hlth, NL-5000 LE Tilburg, Netherlands. [De Vries, J.] St Elisabeth Hosp Tilburg, Tilburg, Netherlands. [Dumitrescu, B.] Clin Hosp Dr I Cantacuzino, Bucharest, Romania. [Wolffenbuttel, B. H. R.] Univ Med Ctr Groningen, Dept Endocrinol, NL-9713 AV Groningen, Netherlands. [Wolffenbuttel, B. H. R.] Univ Groningen, Groningen, Netherlands. [Geusens, P.] Univ Hosp Maastricht, Dept Rheumatol, Maastricht, Netherlands. [Geusens, P.] Nutr & Toxicol Res Inst Maastricht NUTRIM, Maastricht, Netherlands. [Geusens, P.] Univ Hasselt, Biomed Res Inst, Hasselt, Belgium.
URI: http://hdl.handle.net/1942/9693
DOI: 10.1007/s00198-007-0513-y
ISI #: 000257382200012
ISSN: 0937-941X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2009
Appears in Collections: Research publications

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