Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9553

Title: Different growth patterns of non-small cell lung cancer represent distinct biologic subtypes
Authors: Nia, Peyman Sardari
Colpaert, Cecile
Vermeulen, Peter
Pezzella, Francesco
Van Schil, Paul
Van Marck, Eric
Issue Date: 2008
Citation: ANNALS OF THORACIC SURGERY, 85(2). p. 395-405
Abstract: Background. We have recently shown the prognostic value of growth pattern classification in non-small cell lung cancer. The aim of this study is to validate the hypothesis that these growth patterns have a distinct angiogenic and proliferative profile. Methods. Hematoxylin-eosin stained tissue sections of 239 patients with non-small cell lung cancer were classified into growth patterns. One representative tissue section per patient was double immunostained with CD34 and Ki-67 antibodies. Endothelial cell proliferation fraction, tumor cell proliferation fraction, microvessel density, and Chalkley count were assessed at the invading front and the center of the selected tumor section. Results. According to the growth pattern classification, 161 patients (67.4%) had a destructive, 33 (13.8%) a papillary, and 45 (18.8%) an alveolar growth pattern. There were significant differences in endothelial cell proliferation fraction (p < 0.001), tumor cell proliferation fraction (p < 0.001), microvessel density (p < 0.001), and Chalkley count (p < 0.001) between the growth patterns. Multiple Cox regression analysis showed that a low endothelial cell proliferation fraction was consistently an independent prognostic factor for overall poor (hazard ratio = 0.93; confidence interval: 0.88 to 0.97, p = 0.002) and disease-free survival (hazard ratio = 0.94; confidence interval: 0.89 to 0.98, p = 0.007). Conclusions. Growth patterns have a distinct angiogenic and proliferative profile. In non-small cell lung cancer, a low degree of angiogenesis (a low endothelial cell proliferation fraction) is associated with poor prognosis.
Notes: Univ Antwerp Hosp, Dept Thorac & Vasc Surg, Antwerp, Belgium. Univ Antwerp Hosp, Dept Pathol, Antwerp, Belgium. Univ Antwerp Hosp, Dept Epidemiol, Antwerp, Belgium. Univ Antwerp Hosp, Dept Social Med, Antwerp, Belgium. John Radcliffe Hosp, Canc Res Tumor Pathol Grp, Oxford OX3 9DU, England.
URI: http://hdl.handle.net/1942/9553
DOI: 10.1016/j.athoracsur.2007.08.054
ISI #: 000252664900007
ISSN: 0003-4975
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

Files in This Item:

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.