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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9290

Title: Evaluation of Biomarkers for Pharmacological Activity
Authors: Alonso Abad, Ariel
Molenberghs, Geert
Renard, Didier
Darstein, Christelle
Issue Date: 2009
Abstract: In recent years the cost of drug development has increased the demands on efficiency in the selection of suitable drug candidates. Biomarkers for efficacy and safety could be a plausible strategy to improve this selection process. In the present work, we focus on the study and evaluation of different physiological variables as biomarkers for pharmacological activity. We proposed three different approaches using multivariate and univariate techniques. We note that even though one could argue that the multivariate procedure is more powerful than the other alternatives, the univariate methods also offer a great flexibility to answer interesting scientific questions. The three approaches were used to analyze a crossover study involving an opioid antagonist.
Notes: [Alonso, Ariel; Molenberghs, Geert] Hasselt Univ, Ctr Stat, B-3590 Diepenbeek, Belgium. [Renard, Didier] Novartis Pharma AG, Exploratory Dev, Clin Informat Sci, Basel, Switzerland. [Darstein, Christelle] Lilly Corp Ctr, Lilly Serv SA, Program Phase Stat, Indianapolis, IN USA.
URI: http://hdl.handle.net/1942/9290
DOI: 10.1080/10543400802622386
ISI #: 000263291400003
ISSN: 1054-3406
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

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