Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9246

Title: Intrauterine Exposure to Environmental Pollutants and Body Mass Index during the First 3 Years of Life
Authors: Verhulst, Stijn L.
Nelen, Vera
Den Hond, Elly
Koppen, Gudrun
Vael, Carl
Schoeters, Greet
Desager, Kristine
Issue Date: 2009
Abstract: OBJECTIVE: We investigated the association between body mass index (BMI) standard deviation score (SDS) and prenatal exposure to hexachlorobenzene, dichlorodiphenyldichloroethylene (DDE), dioxin-like compounds, and polychlorinated biphenyls (PCBs). METHODS: In this prospective birth cohort study, we assessed a random sample of mother-infant pairs (n = 138) living in Flanders, Belgium, with follow-up until the children were 3 years of age. We measured body mass index as standard deviation scores (BMI SDS) of children 1-3 years of age as well as pollutants measured in cord blood. RESULTS: DDE correlated with BMI SDS, with effect modification by maternal smoking and the child's age. At I year, children of smoking mothers had higher BMI SDS than did children of nonsmoking mothers. At 3 years, this difference was reduced because of the Faster rate of decline in BMI SDS in the former group. This relationship held except for children with high levels of DDE. DDE had a small effect on BMI SDS at 3 years of age in children of nonsmoking mothers (difference in BMI SIDS for DDE concentrations between the 90th and 10th percentiles = 0.13). On the other hand, smoking enhanced the relation between DDE and BMI SIDS at 3 years (difference in BMI SDS for DDE concentrations between the 90th and 10th percentiles = 0.76). Increasing concentrations of PCBs were associated with higher BMI SDS values at all ages (parameter estimate = 0.003 +/- 0.001; p = 0.03). CONCLUSION: In this study we demonstrated that intrauterine exposure to DDE and PCBs is associated with BMI during early childhood. Future studies are warranted to confirm our findings and to assess possible mechanisms by which these pollutants could alter energy metabolism.
Notes: [Verhulst, Stijn L.; Desager, Kristine] Univ Antwerp, Dept Pediat, B-2610 Antwerp, Belgium. [Den Hond, Elly; Koppen, Gudrun; Schoeters, Greet] Vlaamse Instelling Technol Onderzoek, Flemish Inst Technol Res, B-2400 Mol, Belgium. [Nelen, Vera] Prov Inst Hyg, Antwerp, Belgium. [Den Hond, Elly; Koppen, Gudrun; Schoeters, Greet] Univ Antwerp, Dept Biomed Sci, B-2020 Antwerp, Belgium. [Beunckens, Caroline] Hasselt Univ, Ctr Stat, Hasselt, Belgium. [Vael, Carl] Univ Antwerp, Dept Microbiol, B-2020 Antwerp, Belgium.
URI: http://hdl.handle.net/1942/9246
DOI: 10.1289/ehp.0800003
ISI #: 000262483900040
ISSN: 0091-6765
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

Files in This Item:

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.