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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9216

Title: Contact patterns and their implied basic reproductive numbers: an illustration for varicella-zoster virus
Authors: Van Effelterre, Thierry
Shkedy, Ziv
Aerts, Marc
Molenberghs, Geert
Van Damme, P.
Beutels, P.
Issue Date: 2009
Citation: EPIDEMIOLOGY AND INFECTION, 137(1). p. 48-57
Abstract: The WAIFW matrix (Who Acquires Infection From Whom) is a central parameter in modelling the spread of infectious diseases. The calculation of the basic reproductive number (R-0) depends on the assumptions made about the transmission within and between age groups through the structure of the WAIFW matrix and different structures might lead to different estimates for R-0 and hence different estimates for the minimal immunization coverage needed for the elimination of the infection in the population. In this paper, we estimate R-0 for varicella in Belgium. The force of infection is estimated from seroprevalence data using fractional polynomials and we show how the estimate of R-0 is heavily influenced by the structure of the WAIFW matrix.
Notes: [Van Effelterre, T.; Shkedy, Z.; Aerts, M.; Molenberghs, G.] Hasselt Univ, Ctr Stat Biostat, B-3590 Diepenbeek, Belgium. [Van Damme, P.; Beutels, P.] Univ Antwerp, Ctr Evaluat Vaccinat, B-2020 Antwerp, Belgium. [Beutels, P.] Univ Sydney, Natl Ctr Immunizat Res & Surveillance, Sydney, NSW 2006, Australia.
URI: http://hdl.handle.net/1942/9216
DOI: 10.1017/S0950268808000563
ISI #: 000262067800005
ISSN: 0950-2688
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

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