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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9215

Title: New Concepts on the Pathogenesis of Autoimmune Diseases: A Role for Immune Homeostasis, Immunoregulation, and Immunosenescence
Authors: Thewissen, Marielle
Stinissen, Piet
Issue Date: 2008
Citation: CRITICAL REVIEWS IN IMMUNOLOGY, 28(5). p. 363-376
Abstract: Complex autoimmune diseases are chronic conditions initiated by a loss of immunological tolerance to self-antigens. Despite many years of intense investigation, the etiopathogenic mechanisms initiating these chronic inflammatory conditions remain undefined. The relatively high prevalence and the clustering of multiple autoimmune diseases within individuals or within families suggest that rather common immune mechanisms may facilitate the development of autoimmune diseases. However, specific genetic or environmental factors seem to be necessary for triggering disease. Clearly, immune mechanisms, which are intended to protect from disease, fail or become dysregulated. In this review, we discuss the mechanisms of immune homeostasts, immune regulation, and immunosenescence. We focus on the merit, consequences, and/or shortcomings of these mechanisms and speculate on their possible involvement in autoimmune-disease development.
Notes: [Thewissen, Marielle; Stinissen, Piet] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Thewissen, Marielle; Stinissen, Piet] Transnatl Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium. [Thewissen, Marielle] Maastricht Univ, Dept Internal Med, Div Clin & Expt Immunol, Cardiovasc Res Inst Maastricht, Maastricht, Netherlands.
URI: http://hdl.handle.net/1942/9215
ISI #: 000262059000001
ISSN: 1040-8401
Category: A1
Type: Journal Contribution
Validation: ecoom, 2010
Appears in Collections: Research publications

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