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|Title: ||Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients|
|Authors: ||Rafter, Joseph|
Karlsson, Pernilla C.
O'Sullivan, Gerald C.
Van Loo, Jan
Collins, John K.
|Issue Date: ||2007|
|Publisher: ||AMER SOC CLINICAL NUTRITION|
|Citation: ||AMERICAN JOURNAL OF CLINICAL NUTRITION, 85(2). p. 488-496|
|Abstract: ||Background: Animal studies suggest that prebiotics and probiotics exert protective effects against tumor development in the colon, but human data supporting this suggestion are weak. Objective: The objective was to verify whether the prebiotic concept (selective interaction with colonic flora of nondigested carbohydrates) as induced by a synbiotic preparation-oligofructose-enriched inulin (SYN1) + Lactobacillus rhamnosus GG (LGG) and Bifidobacterium lactis Bb12 (BB12)-is able to reduce the risk of colon cancer in humans. Design: The 12-wk randomized, double-blind, placebo-controlled trial of a synbiotic food composed of the prebiotic SYN1 and probiotics LGG and BB12 was conducted in 37 colon cancer patients and 43 polypectomized patients. Fecal and blood samples were obtained before, during, and after the intervention, and colorectal biopsy samples were obtained before and after the intervention. The effect of synbiotic consumption on a battery of intermediate biomarkers for colon cancer was examined. Results: Synbiotic intervention resulted in significant changes in fecal flora: Bifidobacterium and Lactobacillus increased and Clostridium perfringens decreased. The intervention significantly reduced colorectal proliferation and the capacity of fecal water to induce necrosis in colonic cells and improve epithelial barrier function in polypectomized patients. Genotoxicity assays of colonic biopsy samples indicated a decreased exposure to genotoxins in polypectomized patients at the end of the intervention period. Synbiotic consumption prevented an increased secretion of interleukin 2 by peripheral blood mononuclear cells in the polypectomized patients and increased the production of interferon gamma in the cancer patients. Conclusions: Several colorectal cancer biomarkers can be altered favorably by synbiotic intervention.|
|Notes: ||ORAFTI, Res & Qual, B-3300 Tienen, Belgium. Karolinska Inst, Dept Med Nutr, Huddinge, Sweden. Mercy Univ Hosp, Cork, Ireland. Univ Coll Cork, Cork Canc Res Ctr, Cork, Ireland. Univ Coll Cork, Dept Microbiol, Cork, Ireland. Univ Coll Cork, Dept Med, Cork, Ireland. Univ Florence, Dept Pharmacol, Florence, Italy. Univ Ulster, No Ireland Ctr Food & Hlth, Coleraine BT52 1SA, Londonderry, North Ireland. Univ Jena, Dept Nutrit Toxicol, D-6900 Jena, Germany. Tech Univ Munich, Dept Food & Nutr, D-8000 Munich, Germany. Fed Res Ctr Nutr & Food, Inst Nutrit Physiol, Karlsruhe, Germany. Univ Hasselt, Hasselt, Belgium.|
|ISI #: ||000244290200024|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2008|
|Appears in Collections: ||Research publications|
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