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|Title: ||Biocompatibility of a new radiopaque iodine-containing acrylic bone cement|
|Authors: ||van Hooy-Corstjens, Catharina S. J.|
Bulstra, Sjoerd K.
Knetsch, Menno L. W.
|Issue Date: ||2007|
|Citation: ||JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 80B(2). p. 339-344|
|Abstract: ||Radiopacity in the vast majority of the commercially available acrylic bone cements that are used clinically is provided by particles of either BaSO4 or ZrO2. Literature reports have shown these agents to have a detrimental effect on some mechanical properties of the cements as well as on its biological response. We, therefore, have developed a new type of bone cement, for which radiopacity results from the presence of an iodine-containing methacrylic copolymer. The focus of the present work was the comparison of the biocompatibillity of this new cement and a commercially available cement that contains barium sulfate. In vitro experiments show that both cements are cytocompatible materials, for which no toxic leachables are found. Implantation of the cements in a rabbit for three months resulted in the occasional presence of a thin fibrous tissue at the cement-bone interface, which is common for acrylic bone cements. Consideration of all the results led to the conclusion that the new cement is as biocompatible as the BaSO4-containing one. (c) 2006 Wiley Periodicals, Inc.|
|Notes: ||Univ Maastricht, Ctr Biomat Res, NL-6200 MD Maastricht, Netherlands. Univ Groningen, Univ Med Ctr Groningen, Dept Orthopaed Surg, NL-9700 RB Groningen, Netherlands. Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Engn, NL-9700 RB Groningen, Netherlands. Acad Hosp Maastricht, Dept Rheumatol, NL-6202 AZ Maastricht, Netherlands. Biomed Res Inst, Hasselt, Belgium.|
|ISI #: ||000243866500008|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2008|
|Appears in Collections: ||Research publications|
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