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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/9026

Title: Design of a new pulsatile bioreactor for tissue engineered aortic heart valve formation
Authors: Dumont, K
Yperman, J
Verbeken, E
Segers, P
Meuris, Bart
Vandenberghe, S
Flameng, W
Verdonck, PR
Issue Date: 2002
Citation: ARTIFICIAL ORGANS, 26(8). p. 710-714
Abstract: Evidence has been gathered that biomechanical factors have a significant impact on cell differentiation and behavior in in vitro cell cultures. The aim of this bioreactor is to create a physiological environment in which tissue engineered (TE) aortic valves seeded with human cells can be cultivated during a period of several days. The bioreactor consists of 2 major parts: the left ventricle (LV) and the afterload consisting of a compliance, representing the elastic function of the large arteries, and in series a resistance, mimicking the arterioles and capillaries. The TE aortic valve is placed between the LV and the compliance. With controllable resistance, compliance, stroke volume and frequency, and hydrodynamic conditions can be changed over a wide physiological range. This study resulted in a prototype of a compact pulsatile flow system for the creation of TE aortic valves. In addition a biocompatibility study of the used materials is performed.
Notes: State Univ Ghent, Inst Biomed Technol, Hydraul Lab, B-9000 Ghent, Belgium. Katholieke Univ Leuven, Ctr Expt Surg & Anesthesiol, CEHA, Louvain, Belgium. Katholieke Univ Leuven, Div Morphol & Mol Pathol, Louvain, Belgium.
URI: http://hdl.handle.net/1942/9026
ISI #: 000177080800009
ISSN: 0160-564X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2003
Appears in Collections: Research publications

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