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|Title: ||Short- and long-term limbic abnormalities after experimental febrile seizures|
|Authors: ||Jansen, Jacobus F. A.|
Lemmens, Evi M. P.
Strijkers, Gustav J.
Prompers, Jeanine J.
Schijns, Olaf E. M. G.
Kooi, M. Eline
Backes, Walter H.
|Issue Date: ||2008|
|Publisher: ||ACADEMIC PRESS INC ELSEVIER SCIENCE|
|Citation: ||NEUROBIOLOGY OF DISEASE, 32(2). p. 293-301|
|Abstract: ||Experimental febrile seizures (FS) are known to promote hyperexcitability of the limbic system and increase the risk for eventual temporal lobe epilepsy (TLE). Early markers of accompanying microstructural and metabolic changes may be provided by in vivo serial MRI. FS were induced in 9-day old rats by hyperthermia. Quantitative multimodal MRI was applied 24 h and 8 weeks later, in rats with FS and age-matched controls, and comprised hippocampal volumetry and proton spectroscopy, and cerebral T2 relaxometry and diffusion tensor imaging (DTI). At 9 weeks histology was performed. Hippocampal T2 relaxation time elevations appeared to be transient. DTI abnormalities detected in the amygdala persisted up to 8 weeks. Hippocampal volumes were not affected. Histology showed increased fiber density and anisotropy in the hippocampus, and reduced neuronal surface area in the amygdala. Quantitative serial MRI is able to detect transient, and most importantly, long-term FS-induced changes that reflect microstructural alterations. (C) 2008 Elsevier Inc. All rights reserved.|
|Notes: ||[Lemmens, Evi M. P.; Schijns, Olaf E. M. G.; Beuls, Emile A. M.; Hoogland, Govert] Maastricht Univ Hosp, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands. [Jansen, Jacobus F. A.; Kooi, M. Eline; Backes, Walter H.] Maastricht Univ Hosp, Dept Radiol, NL-6202 AZ Maastricht, Netherlands. [Jansen, Jacobus F. A.; Strijkers, Gustav J.; Prompers, Jeanine J.; Nicolay, Klaas] Eindhoven Univ Technol, Biomed NMR, Dept Biomed Engn, NL-5600 MB Eindhoven, Netherlands. [Lemmens, Evi M. P.] Maastricht Univ, Div Neurosci, Sch Mental Hlth & Neurosci, Maastricht, Netherlands. [Beuls, Emile A. M.] Hasselt Univ, Dept Anat & Mat Res, Diepenbeek, Belgium.|
|ISI #: ||000260549100011|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2009|
|Appears in Collections: ||Research publications|
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