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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/8997

Title: Short- and long-term limbic abnormalities after experimental febrile seizures
Authors: Jansen, Jacobus F. A.
Lemmens, Evi M. P.
Strijkers, Gustav J.
Prompers, Jeanine J.
Schijns, Olaf E. M. G.
Kooi, M. Eline
BEULS, Emile
Nicolay, Klaas
Backes, Walter H.
Hoogland, Govert
Issue Date: 2008
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation: NEUROBIOLOGY OF DISEASE, 32(2). p. 293-301
Abstract: Experimental febrile seizures (FS) are known to promote hyperexcitability of the limbic system and increase the risk for eventual temporal lobe epilepsy (TLE). Early markers of accompanying microstructural and metabolic changes may be provided by in vivo serial MRI. FS were induced in 9-day old rats by hyperthermia. Quantitative multimodal MRI was applied 24 h and 8 weeks later, in rats with FS and age-matched controls, and comprised hippocampal volumetry and proton spectroscopy, and cerebral T2 relaxometry and diffusion tensor imaging (DTI). At 9 weeks histology was performed. Hippocampal T2 relaxation time elevations appeared to be transient. DTI abnormalities detected in the amygdala persisted up to 8 weeks. Hippocampal volumes were not affected. Histology showed increased fiber density and anisotropy in the hippocampus, and reduced neuronal surface area in the amygdala. Quantitative serial MRI is able to detect transient, and most importantly, long-term FS-induced changes that reflect microstructural alterations. (C) 2008 Elsevier Inc. All rights reserved.
Notes: [Lemmens, Evi M. P.; Schijns, Olaf E. M. G.; Beuls, Emile A. M.; Hoogland, Govert] Maastricht Univ Hosp, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands. [Jansen, Jacobus F. A.; Kooi, M. Eline; Backes, Walter H.] Maastricht Univ Hosp, Dept Radiol, NL-6202 AZ Maastricht, Netherlands. [Jansen, Jacobus F. A.; Strijkers, Gustav J.; Prompers, Jeanine J.; Nicolay, Klaas] Eindhoven Univ Technol, Biomed NMR, Dept Biomed Engn, NL-5600 MB Eindhoven, Netherlands. [Lemmens, Evi M. P.] Maastricht Univ, Div Neurosci, Sch Mental Hlth & Neurosci, Maastricht, Netherlands. [Beuls, Emile A. M.] Hasselt Univ, Dept Anat & Mat Res, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/8997
DOI: 10.1016/j.nbd.2008.07.010
ISI #: 000260549100011
ISSN: 0969-9961
Category: A1
Type: Journal Contribution
Validation: ecoom, 2009
Appears in Collections: Research publications

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