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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/8552

Title: Penicillin detection with nanocrystalline-diamond field-effect sensor
Authors: Abouzar, Maryam H.
Poghossian, Arshak
Razavi, Arash
Besmehn, Astrid
BIJNENS, Nathalie
WILLIAMS, Oliver
HAENEN, Ken
WAGNER, Patrick
Schoening, Michael J.
Issue Date: 2008
Publisher: WILEY-V C H VERLAG GMBH
Citation: PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 205(9). p. 2141-2145
Abstract: Nanocrystalline-diamond (NCD) films have been utilised for the detection of penicillin G for the first time. The developed penicillin-sensitive biosensor consists of a field-effect capacitive electrolyte-diamond-insulator-semiconductor (EDIS) structure with an immobilised enzyme layer that covers the gate region of the sensor. Undoped NCD thin films of about 100 nm thickness were grown on a p-Si-SiO2 (50 nm thermally grown SiO2) structure by microwave plasma-enhanced chemical vapour deposition. The enzyme penicillinase has been adsorptively immobilised directly onto the O-terminated NCD surface. The EDIS biosensors have been characterised in buffer solutions with different content of penicillin G by means of capacitance-voltage and constant-capacitance method. The developed penicillin biosensor possesses a low detection limit of 5 mu M and a high sensitivity of 6070 mV/decade in a wide linear range of 0.005-2.5 mM penicillin G concentration. (C) 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Notes: [Abouzar, Maryam H.; Poghossian, Arshak; Razavi, Arash; Schoening, Michael J.] Aachen Univ Appl Sci, INB, D-52428 Julich, Germany. [Abouzar, Maryam H.; Poghossian, Arshak; Razavi, Arash; Schoening, Michael J.] Res Ctr Julich GmbH, Inst Bio & Nanosyst IBN 2, D-52425 Julich, Germany. [Bijnens, Nathalile; Williams, Oliver A.; Haenen, Ken; Wagner, Patrick] Hasselt Univ, Inst Mat Res, B-3590 Diepenbeek, Belgium. [Williams, Oliver A.; Haenen, Ken] IMEC VZW, Div IMOMEC, B-3590 Diepenbeek, Belgium. [Besmehn, Astrid] Res Ctr Julich GmbH, Cent Div Analyt Chem ZCH, D-52425 Julich, Germany.
URI: http://hdl.handle.net/1942/8552
DOI: 10.1002/pssa.200879713
ISI #: 000259653700008
ISSN: 1862-6300
Category: A1
Type: Journal Contribution
Validation: ecoom, 2009
Appears in Collections: Research publications

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