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|Title: ||Adalimumab (Humira (R)) effectively prevents uveitis flares in patients with ankylosing spondylitis (AS)|
|Authors: ||Rudwaleit, M.|
|Issue Date: ||2008|
|Publisher: ||CLINICAL & EXPER RHEUMATOLOGY|
|Citation: ||CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 26(4). p. 741-741|
|Abstract: ||Objective: To investigate effects of adalimumab on uveitis episodes in AS. Methods: AS patients with BASDAI≥4 despite ≥1 NSAID received open-label
adalimumab 40 mg every other week for 12 weeks (RHAPSODY). History of
uveitis (≥1 prior uveitis fl are) was documented and characterized as acute (AU) or
chronic (persistent uveitis with symptom-free interval <3 months to next relapse).
Uveitis episodes within past year prior to baseline were reported as “0 fl ares,” “1–2
fl ares,” or “≥3 fl ares.” Rates of previous fl ares per 100-patient years (100-PYs) during
the past year were calculated using mean of 1–2 fl ares (1.5) and minimum of ≥3
(3.0) fl ares. Rate of uveitis fl ares reported as AEs was calculated as events per 100-
PYs. Uveitis fl ares/100-PYs before vs. during adalimumab therapy were compared.
Results: Of 1,250 patients, 25 (2%) reported 27 AU fl ares. Of 274 who had a history
of uveitis, 23 (8%) reported 25 AU fl ares. Of 106 patients with symptomatic
AU in the past year, 19 (18%) reported 21 AU fl ares. Of 28 with active AU at baseline,
9 (32%) reported 10 AU fl ares. New-onset uveitis occurred in 2 males. Of 274
with prior uveitis, 43 had chronic uveitis; 10 fl ares occurred during adalimumab
therapy in this group.|
|Notes: ||Charite Campus Benjamin Franklin, Berlin, Germany. St Olavs Hosp, Trondheim, Norway. Reg Hosp Silkeborg, Silkeborg, Denmark. Univ Hasselt, Hasselt, Belgium. Abbott GmbH & Co KG, Ludwigshafen, Germany.|
|ISI #: ||000259275600146|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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