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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/8460

Title: Fitting conditional survival models to meta-analytic data by using a transformation toward mixed-effects models
Authors: MASSONNET, Goele
Issue Date: 2008
Citation: BIOMETRICS, 64(3). p. 834-842
Abstract: Frailty models are widely used to model clustered survival data. Classical ways to fit frailty models are likelihood-based. We propose an alternative approach in which the original problem of "fitting a frailty model" is reformulated into the problem of "fitting a linear mixed model" using model transformation. We show that the transformation idea also works for multivariate proportional odds models and for multivariate additive risks models. It therefore bridges segregated methodologies as it provides a general way to fit conditional models for multivariate survival data by using mixed models methodology. To study the specific features of the proposed method we focus on frailty models. Based on a simulation study, we show that the proposed method provides a good and simple alternative for fitting frailty models for data sets with a sufficiently large number of clusters and moderate to large sample sizes within covariate-level subgroups in the clusters. The proposed method is applied to data from 27 randomized trials in advanced colorectal cancer, which are available through the Meta-Analysis Group in Cancer.
Notes: Hasselt Univ, Ctr Stat, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/8460
DOI: 10.1111/j.1541-0420.2007.00960.x
ISI #: 000258470600019
ISSN: 0006-341X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2009
Appears in Collections: Research publications

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