Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/8445

Title: Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study
Authors: De Coster, S
Koppen, G
Bracke, M
Schroijen, C
Den Hond, E
Nelen, V
de Mieroop, EV
BRUCKERS, Liesbeth
Bilau, M.
Baeyens, W.
Schoeters, G.
van Larebeke, N.
Issue Date: 2008
Abstract: Background: This study intended to investigate whether residence in areas polluted by heavy industry, waste incineration, a high density of traffic and housing or intensive use of pesticides, could contribute to the high incidence of cancer observed in Flanders. Methods: Subjects were 1583 residents aged 50 -65 from 9 areas with different types of pollution. Cadmium, lead, p, p'-DDE, hexachlorobenzene, PCBs and dioxin-like activity (Calux test) were measured in blood, and cadmium, t, t'-muconic acid and 1-hydroxypyrene in urine. Effect biomarkers were prostate specific antigen, carcinoembryonic antigen and p53 protein serum levels, number of micronuclei per 1000 binucleated peripheral blood cells, DNA damage (comet assay) in peripheral blood cells and 8-hydroxy-deoxyguanosine in urine. Confounding factors were taken into account. Results: Overall significant differences between areas were found for carcinoembryonic antigen, micronuclei, 8-hydroxy-deoxyguanosine and DNA damage. Compared to a rural area with mainly fruit production, effect biomarkers were often significantly elevated around waste incinerators, in the cities of Antwerp and Ghent, in industrial areas and also in other rural areas. Within an industrial area DNA strand break levels were almost three times higher close to industrial installations than 5 kilometres upwind of the main industrial installations (p < 0.0001). Positive exposure-effect relationships were found for carcinoembryonic antigen (urinary cadmium, t, t'-muconic acid, 1-hydroxypyrene and blood lead), micronuclei (PCB118), DNA damage (PCB118) and 8-hydroxy-deoxyguanosine (t, t'-muconic acid, 1-hydroxypyrene). Also, we found significant associations between values of PSA above the p90 and higher values of urinary cadmium, between values of p53 above the p90 and higher serum levels of p, p'-DDE, hexachlorobenzene and marker PCBs (PCB 138, 153 and 180) and between serum levels of p, p'-DDE above the p90 and higher serum values of carcinoembryonic antigen. Significant associations were also found between effect biomarkers and occupational or lifestyle parameters. Conclusion: Levels of internal exposure, and residence near waste incinerators, in cities, or close to important industries, but not in areas with intensive use of pesticides, showed positive correlations with biomarkers associated with carcinogenesis and thus probably contribute to risk of cancer. In some rural areas, the levels of these biomarkers were not lower than in the rest of Flanders.
Notes: Ghent Univ Hosp, Study Ctr Carcinogenesis & Primary Prevent Canc, Dept Radiotherapy Nucl Med & Expt Cancerol, B-9000 Ghent, Belgium. Vlaamse Instelling Technol Onderzoek, Flemish Inst Technol Res, B-2400 Mol, Belgium. Ghent Univ Hosp, Lab Expt Cancerol, Dept Radiotherapy Nucl Med & Expt Cancerol, B-9000 Ghent, Belgium. Vrije Univ Brussels, B-1050 Brussels, Belgium. Prov Inst Hyg, B-2000 Antwerp, Belgium. Univ Hasselt, B-3590 Diepenbeek, Belgium. Univ Ghent, Dept Publ Hlth, B-9000 Ghent, Belgium.
URI: http://hdl.handle.net/1942/8445
DOI: 10.1186/1476-069X-7-26
ISI #: 000257560300001
ISSN: 1476-069X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2009
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
Postprint1.66 MBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.