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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/8414

Title: Treatment of myasthenia gravis by preventing acetylcholine receptor modulation
Authors: Losen, M
Martinez-Martinez, Pilar
Phernambucq, M
Schuurman, J
Parren, PWWI
DE BAETS, Marc
Issue Date: 2008
Publisher: BLACKWELL PUBLISHING
Citation: Kaminski, HJ & Barohn, RJ (Ed.) MYASTHENIA GRAVIS AND RELATED DISORDERS: 11TH INTERNATIONAL CONFERENCE. p. 174-179.
Series/Report: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1132
Abstract: Myasthenia gravis (MG) is an autoimmune disease caused by antibodies mainly directed to the acetylcholine receptor (AChR) of the neuromuscular junction. Induction of antigenic modulation and complement activation by such autoantibodies leads to ultrastructural damage of the postsynaptic membrane and loss of AChR and associated proteins. Reduction of antigenic modulation by increasing the expression of the receptor-associated anchor protein, rapsyn, or by functionally monovalent competing IgG4 anti-AChR antibodies was shown to prevent MG disease activity. We propose that preventing antigenic modulation can be used as a treatment strategy for MG.
Notes: Univ Maastricht, Neuroimmunol Grp, Inst Mental Hlth & Neurosci,Dept Neurosci, Netherlands European Grad Sch Neuro EURON, Maastricht, NL-6229 ER Netherlands. Genmab, Utrecht, Netherlands. Hasselt Univ, Neuroimmunol Grp, Biomed Res Inst BIOMED, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/8414
DOI: 10.1196/annals.1405.034
ISI #: 000257139900021
ISBN: 978-1-57331-687-3
ISSN: 0077-8923
Category: C1
Type: Proceedings Paper
Validation: ecoom, 2009
Appears in Collections: Research publications

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