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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/8328

Title: Altered ingestive behavior, weight changes, and intact olfactory sense in an APP overexpression model
Authors: Vloeberghs, Ellen
Van Dam, Debby
Franck, Frieda
Staufenbiel, Matthias
Serroyen, Jan
Molenberghs, Geert
De Deyn, Peter Paul
Issue Date: 2008
Citation: BEHAVIORAL NEUROSCIENCE, 122(3). p. 491-497
Abstract: Transgenic APP23 mice were generated to model Alzheimer's disease. The APP23 model develops pathological features, learning deficits, and memory deficits analogous to dementing patients. In this report, transgenic mice exhibited several behavioral disturbances indicating the presence of neuropsychiatric symptoms of dementia. Aiming to verify whether the model also develops other behavioral problems, the authors investigated ingestive behavior in APP23 males of 3, 6 and 12 months. In addition, body weights of a naive male group were longitudinally monitored starting at weaning. Olfactory acuity was evaluated in mice of different age groups. Although olfactory functioning of APP23 mice appeared intact, they drank more and took more food pellets compared with wild-type littermates during a 1-week registration period. From the age of 4.5 weeks onward, APP23 males weighed significantly less than their control littermates, whereas this difference became more prominent with increasing age. Our results suggest the presence of a hypermetabolic state in this model. This is the first report, evidencing the presence of changes in eating and drinking behavior in a single transgenic Alzheimer mouse model.
Notes: Univ Antwerp, Dept Biomed Sci, Inst Born Bunge, Lab Neurochem & Behav, B-2610 Antwerp, Belgium. Hasselt Univ, Ctr Stat, Diepenbeek, Belgium. Novartis Inst Biomed Res Basel, Basel, Switzerland. Middleheim Gen Hosp, Memory Clin, Dept Neurol, Antwerp, Belgium.
URI: http://hdl.handle.net/1942/8328
DOI: 10.1037/0735-7044.122.3.491
ISI #: 000256210300001
ISSN: 0735-7044
Category: A1
Type: Journal Contribution
Validation: ecoom, 2009
Appears in Collections: Research publications

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