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Title: Cadmium-induced transcriptional and enzymatic alterations related to oxidative stress
Authors: Smeets, Karen
Ruytinx, Joske
Semane, Brahim
Van Belleghem, Frank
Remans, Tony
Van Sanden, Suzy
Vangronsveld, Jaco
Cuypers, Ann
Issue Date: 2008
Abstract: The early antioxidative defence mechanisms were studied in Arabidopsis thaliana by applying a range of realistic Cd concentrations. Our data suggest that a 24 h exposure to 20 mu M CdSO4 is already too toxic to study moderate toxicity, whereas a highly coordinated oxidative stress-related defence response could be observed after Cd application of 5 and 10 mu M. Significant differences in transcript abundance of several genes involved in antioxidative defence were observed. The generation of superoxide seems the main cause of oxidative stress in the roots, whereas in the leaves hydrogen peroxide appears to be an important player. Furthermore, an increased transcript level of lipoxygenase, a potential inducer of oxidative stress, suggests a central role of this gene in causing the Cd-related redox imbalance. Our results show that Cd as a non-redox-active metal induces oxidative stress and indicate that the antioxidative defence system is moderated by the activation of different genes in different organs and cellular compartments.
Notes: Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. Vrije Univ Brussel VIB, B-1050 Brussels, Belgium. Open Univ Netherlands, Sch Sci, NL-6401 DL Heerlen, Netherlands. Hasselt Univ, Ctr Stat, B-3590 Diepenbeek, Belgium.Smeets, K, Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium.karen.smeets@uhasselt.be
URI: http://hdl.handle.net/1942/8243
DOI: 10.1016/j.envexpbot.2007.10.028
ISI #: 000254671700001
ISSN: 0098-8472
Category: A1
Type: Journal Contribution
Validation: ecoom, 2009
Appears in Collections: Research publications

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