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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/7945

Title: A MIP-based impedimetric sensor for the detection of low-MW molecules
Authors: THOELEN, Ronald
VANSWEEVELT, Rob
DUCHATEAU, Jan
HOREMANS, Frederik
D'HAEN, Jan
LUTSEN, Laurence
VANDERZANDE, Dirk
AMELOOT, Marcel
VAN DE VEN, Martin
CLEIJ, Thomas
WAGNER, Patrick
Issue Date: 2008
Publisher: Elsevier
Citation: BIOSENSORS & BIOELECTRONICS, 23(6). p. 913-918
Abstract: Mimicking the selectivity and sensitivity of biological systems for sensor devices is of increasing interest in biomedical, environmental and chemical analysis. Synthetic materials with imprinted nanocavities, acting as highly selective artificial receptors, are a tailor-made solution in obtaining such a sensor. Incorporation of such molecularly imprinted polymers (MIPs) in a platform suitable for electrochemical measurements, can offer high sensitivity together with device miniaturization and an electronic read-out. As a proof of principle, a MIP-based sensor for L-nicotine has been developed. To this end, the molecular structure of L-nicotine was imprinted in a polymer matrix of polymethacrylic acid (PMAA). Subsequently, microparticles of the imprinted polymer were immobilized on thin films of the conjugated polymer OC1C10-PPV These films were incorporated in an impedimetric sensing device. Using electrochemical impedance spectroscopy, the real part of the impedance was monitored for various concentrations. This setup allows for the detection of L-nicotine from 1 to 10 nM and is insensitive for the resembling molecule L-cotinine. (C) 2007 Elsevier B.V. All rights reserved.
Notes: Hasselt Univ, Inst Mat Res, B-3590 Diepenbeek, Belgium. Div IMOMEC, IMEC, B-3590 Diepenbeek, Belgium. Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. Transnatl Univ Limburg, B-3590 Diepenbeek, Belgium.Thoelen, R, Hasselt Univ, Inst Mat Res, Wetenschapspark 1, B-3590 Diepenbeek, Belgium.ronald.thoelen@uhasselt.beELSEVIER ADVANCED TECHNOLOGYOXFORDOXFORD FULFILLMENT CENTRE THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
URI: http://hdl.handle.net/1942/7945
DOI: 10.1016/j.bios.2007.08.020
ISI #: 000252790000023
ISSN: 0956-5663
Category: A1
Type: Journal Contribution
Validation: ecoom, 2009
Appears in Collections: Research publications

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