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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/7829

Title: Early prediction of major depression in chronic hepatitis C patients during peg-interferon alpha-2b treatment by assessment of vegetative-depressive symptoms after four weeks
Authors: Robaeys, Geert
De Bie, Jozef
Wichers, Marieke C.
Bruckers, Liesbeth
Nevens, F.
Michielsen, Peter
Van Ranst, M.
Buntinx, Frank
Issue Date: 2007
Publisher: W J G PRESS
Citation: WORLD JOURNAL OF GASTROENTEROLOGY, 13(43). p. 5736-5740
Abstract: AIM: To study the predictive value of the vegetative-depressive symptoms of the Zung Depression Rating Scale for the occurrence of depression during treatment with peg-interferon alpha-2b of chronic hepatitis C (CHC) patients. METHODS: The predictive value of vegetative-depressive symptoms at 4 wk of treatment for the occurrence of a subsequent diagnosis of major depressive disorder (MDD) was studied in CHC patients infected after substance use in a prospective, multi-center treatment trial in Belgium. The presence of vegetative-depressive symptoms was assessed using the Zung Scale before and 4 wk after the start of antiviral treatment. RESULTS: Out of 4.9 eligible patients, 19 (39%) developed MDD. The area under the ROC curve of the vegetative Zung subscale was 0.73, P = 0.004. The sensitivity at a cut-point of > 15/35 was 95% (95% CI: 74-100). The positive predictive value equalled 44% (95% CI: 29-60). CONCLUSION: In this group of Belgian CHC patients infected after substance use, antiviral treatment caused a considerable risk of depression. Seven vegetative-depressive symptoms of the Zung scale at wk 4 of treatment predicted 95% of all emerging depressions, at a price of 56% false positive test results. (C) 2007 WJG. All rights reserved.
Notes: Zirkenhuis Oost Limburg, Dept Gastroenterol & Hepatol, B-3600 Genk, Belgium. Zirkenhuis Oost Limburg, Dept Psychiat, B-3600 Genk, Belgium. Maastricht Univ, EURON, South Limburg Mental Hlth Res & Teaching Network, Dept Psychiat & Neuropsychiat, Maastricht, Netherlands. Limburgs Univ, Ctr Stat, Diepenbeek, Belgium. Katholieke Univ Leuven, Dept Hepatol, Louvain, Belgium. Univ Hosp, Div Gastroenterol & Hepatol, Antwerp, Belgium. Katholieke Univ Leuven, Rega Inst, Dept Microbiol & Immunol, Lab Clin & Epidemiol Virol, Louvain, Belgium. Katholieke Univ Leuven, Univ Hosp, Louvain, Belgium. Katholieke Univ Leuven, Dept Gen Practice, Louvain, Belgium. Maastricht Univ, Dept Gen Practice, Maastricht, Netherlands.Robaeys, G, Zirkenhuis Oost Limburg, Dept Gastroenterol & Hepatol, Schiepse Bos 6, B-3600 Genk, Belgium.geert.robaeys@zol.be
URI: http://hdl.handle.net/1942/7829
Link to publication: http://www.wjgnet.com/1007-9327/13/5736.asp
ISI #: 000250799600010
ISSN: 1007-9327
Category: A1
Type: Journal Contribution
Validation: ecoom, 2008
Appears in Collections: Research publications

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