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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/7825

Title: Bone turnover and hip bone mineral density in patients with sarcoidosis
Authors: Heijckmann, A. Caroline
Huijberts, Maya S. P.
De Vries, Jolanda
Menheere, Paul P. C. A.
Van der Veer, Eveline
Kruseman, Arie C. Nieuwenhuijzen
Wolffenbuttel, Bruce H. R.
Drent, Marjolein
Issue Date: 2007
Abstract: Background and aim of the work: Sarcoidosis is a chronic inflammatory T-cell-driven disease can also affect bone. We evaluated bone remodelling and bone mineral density (BMD) in patients with coidosis and their dependency of disease-related and treatment-related factors. Methods: In 124 BMD of the hip (DXA) and markers of bone resorption (ICTP) and formation (PINP) were evaluated. thermore a lateral DXA of the spine for morphometric assessment of vertebral deformities was performed 87 patients. Potential predictors of bone markers, BMD and determinants of prevalent vertebral were assessed using multiple and logistic regression analysis. Results: The population studied comprised treated patients (n = 51), patients that previously used glucocorticoids (n = 31) and patients currently glucocorticoids (n = 42). In all these groups the age- and gender corrected Z-scores of the hip were except in untreated patients, which revealed an increased Z-score at the trochanter (p = 0.004). In all but patients currently on glucocorticoids the Z-scores for PINP and ICTP were increased (p < 0.05). In currently on glucocorticoids the Z-ICTP was also increased (p < 0.05), but the Z-PINP decreased (p < compared to untreated patients). In 20.6% of patients one or more morphometric vertebral deformities found. Conclusions: Hip BMD is normal in patients with sarcoidosis, despite an increased bone turnover. may imply that in sarcoidosis mechanisms are involved that compensate for the well-known effects of tokines in inflammatory diseases on osteoclastogenesis and bone resorption. Nonetheless, vertebral ties suggestive of fracture were found in a significant number of patients which indicates that patients sarcoidosis still have a relevant fracture risk.
Notes: Univ Hosp, Dept Internal Med, Div Endocrinol, Maastricht, Netherlands. Hosp Bernhoven, Dept Internal Med, Oss, Netherlands. Tilburg Univ, St Elisabeth Hosp, Dept Psychol, Tilburg, Netherlands. Univ Hosp, Sarcoidosis Management Team, Maastricht, Netherlands. Univ Hosp Maastricht, Dept Clin Chem, Maastricht, Netherlands. Univ Med Ctr Groningen, Dept Pathol & Lab Med, Groningen, Netherlands. Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands. Univ Hosp, Dept Rheumatol, Maastricht, Netherlands. Univ Hasselt, Biomed Res Inst, Hasselt, Belgium. Dept Resp Med, Maastricht, Netherlands.Heijckmann, AC, Hosp Bernhoven, Dept Internal Med, PO Box 10000, NL-5460 DA Veghel, Netherlands.e.heijckmann@bernhoven.nl
URI: http://hdl.handle.net/1942/7825
ISI #: 000251153700006
ISSN: 1124-0490
Category: A1
Type: Journal Contribution
Validation: ecoom, 2008
Appears in Collections: Research publications

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