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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/7819

Title: CD4(+)CD28(null) T cells in autoimmune disease: Pathogenic features and decreased susceptibility to immunoregulation
Authors: THEWISSEN, Marielle
SOMERS, Veerle
HELLINGS, Niels
FRAUSSEN, Judith
Damoiseaux, Jan
STINISSEN, Piet
Issue Date: 2007
Publisher: AMER ASSOC IMMUNOLOGISTS
Citation: JOURNAL OF IMMUNOLOGY, 179(10). p. 6514-6523
Abstract: To determine the role of expanded CD4(+)CD28(null) T cells in multiple sclerosis and rheumatoid arthritis pathology, these cells were phenotypically characterized and their Ag reactivity was studied. FACS analysis confirmed that CD4(+)CD28(null) T cells are terminally differentiated effector memory cells. In addition, they express phenotypic markers that indicate their capacity to infiltrate into tissues and cause tissue damage. Whereas no reactivity to the candidate autoantigens myelin basic protein and collagen type 11 was observed within the CD4(+)CD28(null) T cell subset, CMV reactivity was prominent in four of four HC, four of four rheumatoid arthritis patients, and three of four multiple sclerosis patients. The level of the CMV-induced proliferative response was found to be related to the clonal diversity of the response. Interestingly, our results illustrate that CD4(+)CD28(null) T cells are not susceptible to the suppressive actions of CD4(+)CD25(+) regulatory T cells. In conclusion, this study provides several indications for a role of CD4(+)CD28(null) T cells in autoimmune pathology. CD4(+)CD28(null) T cells display pathogenic features, fill up immunological space, and are less susceptible to regulatory mechanisms. However, based on their low reactivity to the autoantigens tested in this study, CD4(+)CD28(null) T cells most likely do not play a direct autoaggressive role in autoimmune disease.
Notes: Hasselt Univ, Biomed Onderzoeksinst, Diepenbeek, Belgium. Transnatl Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. Univ Hosp Maastricht, Dept Clin & Expt Immunol, Maastricht, Netherlands.Stinissen, P, Hasselt Univ, Biomed Onderzoeksinst, Agoralaan,Bldg A, Diepenbeek, Belgium.piet.stinissen@uhasselt.be
URI: http://hdl.handle.net/1942/7819
Link to publication: http://www.jimmunol.org/cgi/content/abstract/179/10/6514
ISI #: 000250792700018
ISSN: 0022-1767
Category: A1
Type: Journal Contribution
Validation: ecoom, 2008
Appears in Collections: Research publications

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