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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/7260

Title: Non-compliance, ethical imperative or mission impossible?
Shapiro, S.
Issue Date: 1996
Citation: Statistics in medicine, 15(24). p. 2813-2826
Abstract: Assuming that a drug is active and different from placebo, a patient's gain or loss is likely to depend on how much of the drug is taken and when. The present paper motivates the ethical imperative of statistical compliance analysis by considering important clinical questions, the advent of more precise compliance measuring instruments and new statistical efforts towards well understood analyses that seek to preserve scientific integrity. An extension of Efron and Feldman's approach is developed which exploits the randomization assumption in combination with structural models. It also generates more promising designs and alternative statistical approaches.
URI: http://hdl.handle.net/1942/7260
DOI: 10.1002/(SICI)1097-0258(19961230)15:24<2813::AID-SIM366>3.0.CO;2-U
Type: Journal Contribution
Appears in Collections: Research publications

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