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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/6808

Title: High-dose DTIC in advanced soft-tissue sarcomas in the adult
Authors: Buesa, J.M.
Mouridsen, H.T.
van Oosterom, A.T.
Verweij, J.
Wagener, T.
Steward, W.
Poveda, A.
Vestlev, P.M.
Thomas, D.
SYLVESTER, Richard
Issue Date: 1991
Citation: Annals of oncology, 2. p. 307-309
Abstract: Forty-four of 50 adult patients with advanced soft-tissue sarcoma who had received previous chemotherapy were evaluable for response after treatment with DTIC. The therapeutic schedule consisted of DTIC 1.2 g/m2 infused over 20 minutes, and repeated every 3 weeks. There were 1 complete and 7 partial remissions (objective activity 18%, 95% C.I. 7%-29%), with a median duration of 8 weeks (range 5–19), with the complete remission lasting 1 yr. Hematologic toxicity was dose-limiting; W.H.O. 3 values were observed for WBC in 36%, and for platelets in 26% of patients. The non-hematologic toxicity included nausea and vomiting (90%), a flu-like syndrome (49%), diarrhea (35%), pain in the infused vein (28%) and hypotensive episodes (4%). Intermittent high-dose DTIC is active in advanced soft-tissue sarcoma and should be considered for inclusion in combination regimens.
URI: http://hdl.handle.net/1942/6808
Link to publication: http://annonc.oxfordjournals.org/cgi/content/abstract/2/4/307?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=sylvester&searchid=1&FIRSTINDEX=0&volume=2&issue=4&resourcetype=HWCIT
Type: Journal Contribution
Appears in Collections: Research publications

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