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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/6796

Title: A comparison of group sequential methods for binary longitudinal data
Authors: Spiessens, B.
LESAFFRE, Emmanuel
VERBEKE, Geert
Issue Date: 2003
Publisher: JOHN WILEY & SONS LTD
Citation: Statistics in medicine, 22(4). p. 501-515
Abstract: Interim analyses are conducted to allow for early termination of the trial, for ethical as well as economical reasons. Here we consider interim analyses in repeated measurements studies where the measurements are binary. Two methods for analysing this kind of data are compared according to their operating characteristics. A subject-specific approach based on the logistic random-effects model is compared with the population-averaged approach based on the generalized estimating equations. The comparison is illustrated with simulations using a randomized clinical trial for toenail fungal infection.
URI: http://hdl.handle.net/1942/6796
DOI: 10.1002/sim.1361
ISI #: 000180936300001
ISSN: 0277-6715
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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