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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/674

Title: Prentice's approach and the meta-analytic paradigm: a reflection on the role of statistics in the evaluation of surrogate endpoints
Authors: Alonso Abad, Ariel
Molenberghs, Geert
Burzykowski, Tomasz
Renard, Didier
Geys, Helena
Shkedy, Ziv
Tibaldi, Fabian
Cortinas Abrahantas, Jose
Buyse, Marc E.
Keywords: Surrogate Markers
Longitudinal data
Clinical trials
Issue Date: 2004
Citation: Biometrics, 60(3). p. 724-728
Abstract: We put a perspective on the strengths and limitations of statistical methods for the evaluation of surrogate endpoints. Whereas using several trials overcomes some of the limitations of a single-trial framework (Prentice, 1989, Statistics in Medicine8, 431–440), arguably the evaluation of surrogate endpoints can never be done using only statistical evidence but such evidence should be seen as but one component in a decision-making process that involves, among others, a number of clinical and biological considerations. We briefly present a hierarchical framework that incorporates ideas from Prentice's work and is uniformly applicable to different types of surrogate and true clinical outcomes
URI: http://hdl.handle.net/1942/674
DOI: 10.1111/j.0006-341X.2004.00222.x
ISI #: 000223818200022
Category: A1
Type: Journal Contribution
Validation: ecoom, 2005
Appears in Collections: Research publications

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