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|Title: ||Validation of a longitudinally measured surrogate for a time-to-event endpoint|
|Authors: ||Renard, Didier|
Buyse, Marc E.
Bijnens, Luc J.M.
|Keywords: ||Clinical trials|
|Issue Date: ||2003|
|Publisher: ||CARFAX PUBLISHING|
|Citation: ||Journal of Applied Statistics, 30(2). p. 235-247|
|Abstract: ||The objective of this paper is to extend the surrogate endpoint validation methodology proposed by Buyse et al. (2000) to the case of a longitudinally measured surrogate marker when the endpoint of interest is time to some key clinical event. A joint model for longitudinal and event time data is required. To this end, the model formulation
of Henderson et al. (2000) is adopted. The methodology is applied to a set of two randomized clinical trials in advanced prostate cancer to evaluate the usefulness of
prostate-specific antigen (PSA) level as a surrogate for survival.|
|ISI #: ||000180623500008|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2004|
|Appears in Collections: ||Research publications|
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|Published version||341.67 kB||Adobe PDF|
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