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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/5980

Title: Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age
Authors: Braam, L.A.J.L.M.
Knapen, M.H.J.
GEUSENS, Piet
Brouns, F.
Hamulyák, K.
Gerichhausen, M.J.W.
Vermeer, C.
Issue Date: 2003
Publisher: SPRINGER-VERLAG
Citation: Calcified tissue international, 73(1). p. 21-26
Abstract: Although several observational studies have demonstrated an association between vitamin K status and bone mineral density (BMD) in postmenopausal women, no placebo-controlled intervention trials of the effect of vitamin K-1 supplementation on bone loss have been reported thus far. In the trial presented here we have investigated the potential complementary effect of vitamin K-1 (I mg/day) and a mineral + vitamin D supplement (8 mug/day) on postmenopausal bone loss. The design of our study was a randomized, double-blind, placebo-controlled intervention study; 181 healthy postmenopausal women between 50 and 60 years old were recruited, 155 of whom completed the study. During the 3-year treatment period, participants received a daily supplement containing either placebo, or calcium, magnesium.. zinc, and vitamin D (MD group), or the same formulation with additional vitamin K-1 (MDK group). The main outcome was the change in BMD of the femoral neck and lumbar spine after 3 years, as measured by DXA. The group receiving the supplement containing additional vitamin K-1 showed reduced bone loss of the femoral neck: after 3 years the difference between the MDK and the placebo group was 1.7% (95% Cl: 0.35-3.44) and that between the MDK and MD group was 1.3% (95% Cl: 0.10-3.41). No significant differences were observed among the three groups with respect to change of BMD at the site of the lumbar spine. If co-administered with minerals and vitamin D. vitamin K-1 may substantially contribute to reducing postmenopausal bone loss at the site of the femoral neck.
URI: http://hdl.handle.net/1942/5980
DOI: 10.1007/s00223-002-2084-4
ISI #: 000184185100005
ISSN: 0171-967X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2004
Appears in Collections: Research publications

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