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|Title: ||Verapamil as prophylactic treatment for atrial fibrillation after lung operations|
|Authors: ||VAN MIEGHEM, Walter|
|Issue Date: ||1996|
|Citation: ||Annals of thoracic surgery, 61. p. 1083-1085|
|Abstract: ||Background. Atrial fibrillation is a frequently occurring arrhythmia after thoracic operations. Preventive strategies for this complication have been extensively evaluated after cardiac operations.
Methods. We performed a prospective, open randomized study, comparing intravenous verapamil and placebo in 199 patients after pneumonectomy or lobectomy at the University Hospital of Leuven. Verapamil was administered as a bolus of 10 mg over 2 minutes followed by a 30-minute infusion of 0.375 mg/min and then 0.125 mg/min for 3 days. The patients were continuously monitored in the postoperative intensive care unit.
Results. Atrial fibrillation occurred in 15% of the patients receiving placebo and in 8% of the patients receiving verapamil (difference not significant). The verapamil infusion was interrupted in 9% of the patients because of bradycardia and in 14% because of hypotension.
Conclusions. If tolerated, continuous intravenous verapamil infusion showed only a modest prophylactic efficacy for the occurrence of atrial fibrillation after lung operations. In the dose employed the verapamil infusion was accompanied with a high incidence of side effects necessitating interruption of the therapy.|
|Link to publication: ||http://ats.ctsnetjournals.org/cgi/content/abstract/61/4/1083?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&title=Verapamil+as+prophylactic+treatment+&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT|
|Type: ||Journal Contribution|
|Appears in Collections: ||Non-affiliated authors|
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