Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/5558

Title: The genome of the kinetoplastid parasite, Leishmania major
Authors: Ivens, AC
Peacock, CS
Worthey, CS
Murphy, L
Aggarwal, G.
Berriman, M.
Sisk, E
Rajandream, MA
Adlem, E.
Aert, R
Anupama, A.
Myler, PJ
Apostolou, Z.
Attipoe, P.
Bason, N.
Bauser, C.
Beck, A.
Beverley, SM
Bianchettin, G
Borzym, K
Bothe, G
Bruschi, CV
Collins, M
Cadag, E
Ciarloni, L
Clayton, C
Coulson, RMR
Cronin, A
Cruz, AK
Davies, RM
De Gaudenzi, J
Dobson, DE
Duestrhoeft, A
Fazelina, G
Fosker, N
Frasch, AC
Fraser, A
Fuchs, M
Gabel, C
Goble, A
Goffeau, A
Harris, D
Hertz-Fowler, C
Hilbert, H
Horn, D
Huang, YT
Klages, S
Knights, A
Kube, M
Larke, N
Litvin, L
Lord, A
Louie, T
Marra, M
Masuy, D
Matthews, K
Michaeli, S
Mottram, JC
Muller-Auer, S
Munden, H
Nelson, S
Norbertczak, H
Oliver, K
O'Neil, S
Pentony, M
Pohl, TM
Price, C
Purnelle, B
Quail, MA
Rabbinowitsch, E
Reinhardt, R
Rieger, M
Rinta, J
Robertson, L
Ruiz, JC
Rutter, S
Saunders, D
Schafer, M
Schein, J
Schwartz, DC
Seeger, K
Seyler, A
Sharp, S
Shin, H
Sivam, D
Squares, R
Squares, S
Tosato, V
Vogt, C
Volckaert, G
Wambutt, R
Warren, T
Wedler, H
Woodward, J
Zhou, SG
Zimmerman, W
Smith, DF
Blackwell, JM
Stuart, KD
Barrell, B.
Issue Date: 2005
Citation: Science, 309(5733). p. 436-442
Abstract: Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II–directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression.
URI: http://hdl.handle.net/1942/5558
DOI: 10.1126/science.1112680
ISI #: 000230574900038
ISSN: 0036-8075
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

Files in This Item:

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.