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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/5409

Title: Effectiveness of antiepileptic prophylaxis used with supratentorial craniotomies: a meta-analysis
Authors: Kuylen, Jos M.A.
Teernstra, Onno P.M.
Kessels, Alphons G.A.
Herpers, Marcel J.H.M.
BEULS, Emile
Issue Date: 1997
Publisher: Elsevier Ltd.
Citation: Seizure, 5(4). p. 291-298
Abstract: Thirty publications on the effectiveness of prophylactic antiepileptic drugs (AEDs) with supratentorial craniotomies were reviewed (1980–1995). After a first selection, six controlled studies remained (11 publications). These six were evaluated according to previously defined methodological criteria. The criteria were divided into three main categories: (1) internal validity, (2) proper and relevant outcome-measures and (3) analysis. In this way a maximum of 145 points could be obtained for each study. Three studies were considered to be of satisfactory methodological quality (≥55% of 145 points) and the odds ratios were calculated as a measure of association between treatment and occurrence of convulsions. The odds ratios of these three studies were statistically pooled using the Mantel-Haenszel Estimator. From this test it appeared that prophylactically used AEDs showed a tendency to prevent postoperative convulsions, but this effect was certainly not statistically significant (P = 0.1 one-tailed). Points of attention concerning possible future investigations are stressed.
URI: http://hdl.handle.net/1942/5409
DOI: 10.1016/S1059-1311(96)80023-9
Type: Journal Contribution
Appears in Collections: Research publications

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