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|Title: ||Effectiveness of antiepileptic prophylaxis used with supratentorial craniotomies: a meta-analysis|
|Authors: ||Kuylen, Jos M.A.|
Teernstra, Onno P.M.
Kessels, Alphons G.A.
Herpers, Marcel J.H.M.
|Issue Date: ||1997|
|Publisher: ||Elsevier Ltd.|
|Citation: ||Seizure, 5(4). p. 291-298|
|Abstract: ||Thirty publications on the effectiveness of prophylactic antiepileptic drugs (AEDs) with supratentorial craniotomies were reviewed (1980–1995). After a first selection, six controlled studies remained (11 publications). These six were evaluated according to previously defined methodological criteria. The criteria were divided into three main categories: (1) internal validity, (2) proper and relevant outcome-measures and (3) analysis. In this way a maximum of 145 points could be obtained for each study. Three studies were considered to be of satisfactory methodological quality (≥55% of 145 points) and the odds ratios were calculated as a measure of association between treatment and occurrence of convulsions. The odds ratios of these three studies were statistically pooled using the Mantel-Haenszel Estimator. From this test it appeared that prophylactically used AEDs showed a tendency to prevent postoperative convulsions, but this effect was certainly not statistically significant (P = 0.1 one-tailed). Points of attention concerning possible future investigations are stressed.|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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