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|Title: ||Correlation between the molecular morphology and the biocompatibility of bioadhesive carriers prepared from spray-dried starch/Carbopol® blends|
|Authors: ||Ameye, D.|
|Issue Date: ||2005|
|Citation: ||Polymer, 46(7). p. 2338-2345|
|Abstract: ||Spray-dried Amioca® starch/Carbopol® 974P (C 974P; cross-linked poly(acrylic acid)) blends were evaluated as bioadhesive drug carriers and compared with equivalent physical mixtures. For both mixture types, the nano-morphology was determined by means of SEM and 13C-CP/MAS solid state NMR. Whereas phase separation occurs into individual starch and C 974P. This intimate mixing improves the bioadhesive capacity significantly as compared to equivalent physical mixtures. Up to 20 wt% content of C 974P, the spray-dried blends did not show any sign of irritation. This makes them promising biocompatible powders for application as safe bioadhesive carriers.|
|ISI #: ||000227654500036|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2006|
|Appears in Collections: ||Research publications|
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