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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/4158

Title: The microanatomical environment of the subthalamic nucleus
Authors: Rijkers, Kim
Temel, Yasin
VANORMELINGEN, Linda
VANDERSTEEN, Marjan
ADRIAENSENS, Peter
GELAN, Jan
BEULS, Emile
Visser-Vandewalle, Veerle
Issue Date: 2007
Publisher: AMER ASSOC NEUROLOGICAL SURGEONS
Citation: JOURNAL OF NEUROSURGERY, 107(1). p. 198-201
Abstract: High-frequency stimulation of the subthalamic nucleus (STN) is a widely performed method to treat advanced Parkinson disease. Due to the limitations of current imaging techniques, the 3D microanatomy of the STN and its surrounding structures in the mesencephalon are not well known. Using images they obtained using a 9.4-tesla magnetic resonance (MR) imaging unit, the authors developed a 3D reconstruction of the STN and its immediate surroundings. During the postmortem investigation of a human brain, a sample of tissue in the area around the STN was isolated. This brain tissue was scanned in the three orthogonal planes at 1-mm slice thickness. The images generated were compared with photographs of conventionally stained brain tissue slices in different neuroanatomical books, and a 3D reconstruction was made. High-field MR imaging is an appropriate method for visualizing the microanatomy of the STN and its surroundings. The images allow an optimal analysis of the microenvironment of the STN in the three orthogonal planes and can be used for 3D reconstructions of this area with possible clinical applications in the future.
Notes: Maastricht Univ Hosp, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands. Hasselt Univ, Dept Anat, Hasselt, Belgium. Hasselt Univ, Dept Mat Res, Hasselt, Belgium.Rijkers, K, Maastricht Univ Hosp, Dept Neurosurg, P Debyelaan 25,POB 5800, NL-6202 AZ Maastricht, Netherlands.kimrijkers@gmail.com
URI: http://hdl.handle.net/1942/4158
Link to publication: http://thejns.org/doi/abs/10.3171/JNS-07/07/0198
ISI #: 000247799900031
ISSN: 0022-3085
Category: A1
Type: Journal Contribution
Validation: ecoom, 2008
Appears in Collections: Research publications

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