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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/4098

Title: The ambivalent nature of T-cell infiltration in the central nervous system of patients with multiple sclerosis
Authors: VANDERLOCHT, Joris
Issue Date: 2007
Citation: CRITICAL REVIEWS IN IMMUNOLOGY, 27(1). p. 1-13
Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) of presumed autoimmune origin. On the basis of the pathophysiology of MS, inflammatory reactions in the CNS are considered detrimental. Recent evidence suggests that the injured CNS can also benefit from immune activity. In this review, we will first provide an overview of the mechanisms by which immune cells contribute to CNS injury in MS. We will further review evidence supporting a neuroprotective role of CNS inflammation with special focus on the protective properties of autoimmune reactions. Finally, we discuss the proposed mechanisms by which autoreactive T cells exert protection in the CNS and how this protection is regulated.
Notes: Hasselt Univ, Biomed Onderzoeksinst, B-3590 Diepenbeek, Belgium. Transnatl Univ Limburg, Sch Life Sci, Diepenbeek, Belgium.HELLINGS, N, Hasselt Univ, Biomed Onderzoeksinst, Agoralaan Bldg A, B-3590 Diepenbeek, Belgium.niels.hellings@uhasselt.be
URI: http://hdl.handle.net/1942/4098
Link to publication: http://www.begellhouse.com/journals/2ff21abf44b19838,0a1257122f661a7e,0d878f264b3c71c0.html
ISI #: 000248012600001
ISSN: 1040-8401
Category: A1
Type: Journal Contribution
Validation: ecoom, 2008
Appears in Collections: Research publications

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