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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/4022

Title: Predictors of oligoamenorrhea at 1-year follow-up in premenopausal women using a levonorgestrel-releasing intrauterine system.
Authors: De Jonge, Eric T.
Yigit, Refika
Molenberghs, Geert
Straetmans, Dany
Ombelet, Willem
Issue Date: 2007
Publisher: ELSEVIER SCIENCE INC
Citation: CONTRACEPTION, 76(2). p. 91-95
Abstract: Objective: The study was conducted to identify predictors of oligoamenorrhea at 12 months in levonorgestrel-releasing intrauterine system (LNG-IUS) users. Design: A 12-month observational study. Setting: Gynecologic outpatient clinic in a large regional hospital in Flanders, Belgium. Population or Sample: A total of 150 women who had made an informed decision to use a LNG-IUS either as a method of contraception or to manage menorrhagia. Methods: All women were premenopausal and first-time users. The variables recorded prior to insertion on Days 1 to 5 of the menstrual cycle were age, parity, body mass index, indication for LNG-IUS use, prior contraceptive use, menstrual bleeding history, length of the uterine cavity, endometrial thickness, number of antral follicles, serum follicle-stimulating hormone, inhibin B and anti-Mullerian hormone. Menstrual bleeding pattern, patient satisfaction or wish to discontinue the method was noted at 1, 6 and 12 months of follow-up visits. Main Outcome Measures: Menstrual bleeding pattern (amenorrhea, oligomenorrhea, menorrhagia) at 12 months was taken as the primary outcome measurement. Patient satisfaction was followed as a secondary outcome. Results: Oligoamenorrhea was associated with a high patient satisfaction. A bleeding period less than 5 days, absence of severe uterine bleeding at baseline, LNG-IUS use for contraception and oligoamenorrhea at 3 months were predictors of a favorable outcome at 12 months in a univariate analysis. The absence of severe bleeding prior to LNG-IUS insertion was the only clinically useful predictor of favorable outcome in the multivariate analysis (odds ratio 0.13, 95% confidence interval 0.02-0.66). Conclusions: Patient profiling as described is not helpful in counselling women for intentional LNG-IUS use, especially not if it is planned as a method of managing menorrhagia. (C) 2007 Elsevier Inc. All fights reserved.
Notes: Dept Obstet & Gynecol, B-3600 Genk, Belgium. Hasselt Univ, Ctr Stat, B-3590 Diepenbeek, Belgium. AML Algemeen Med Lab, Lab Clin Pathol, B-2018 Antwerp, Belgium.de Jonge, ET, Dept Obstet & Gynecol, Ziekenhuis Oost Limburg Campus St Jan, B-3600 Genk, Belgium.eric.dejonge@zol.be
URI: http://hdl.handle.net/1942/4022
DOI: 10.1016/j.contraception.2007.04.003
ISI #: 000248534800004
ISSN: 0010-7824
Category: A1
Type: Journal Contribution
Validation: ecoom, 2008
Appears in Collections: Research publications

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