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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3928

Title: A MURINE MONOCLONAL-ANTIBODY TO HUMAN BREAST-CANCER CELLS ASSOCIATED WITH DNA PLOIDY STATUS
Authors: CHIN, Y
PLESSERS, L
VANDEPITTE, J
RAUS, Jef
Issue Date: 1991
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: EUROPEAN JOURNAL OF CANCER, 27(1). p. 48-50
Abstract: A murine monoclonal antibody, 5D10, raised against the human breast cancer cell line MCF7 reacted preferably with mammary carcinomas and weakly with normal epithelial cells. The antigens recognised by the antibody had molecular weights of about 28 and 90 kD. The reactivity of the antibody to human breast carcinomas correlated with the DNA ploidy status of the tumour cells. Upon analysis of 54 breast carcinoma specimens, the percentage of antibody positive cells was significantly higher in tumours with an aneuploid stemline than in those with a diploid DNA content (P < 0.001). This antibody therefore could be a useful tool in evaluating the prognosis of breast carcinomas.
Notes: DR L WILLEMS INST,DEPT IMMUNOL,B-3590 DIEPENBEEK,BELGIUM. SALVATOR HOSP,DEPT PATHOL,HASSELT,BELGIUM.
URI: http://hdl.handle.net/1942/3928
ISI #: A1991FB04500013
ISSN: 0959-8049
Type: Journal Contribution
Appears in Collections: Research publications

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