Document Server@UHasselt >
Research publications >
Please use this identifier to cite or link to this item:
|Title: ||A further exploration of the relationships between immune parameters and the hpa-axis activity in depressed-patients|
|Authors: ||Maes, Michael|
|Issue Date: ||1991|
|Publisher: ||CAMBRIDGE UNIV PRESS|
|Citation: ||PSYCHOLOGICAL MEDICINE, 21(2). p. 313-320|
|Abstract: ||In order to investigate the relationship between the immune apparatus and the hypothalamic-pituitary-adrenal (HPA)-axis activity in depressed patients, we measured in vitro lymphocyte responses to the mitogens Phytohaemagglutinin (PHA), Pokeweed (PWM) and Concanavalin A (Con A) and 8 a.m. baseline cortisol values in plasma, free cortisol excretion in 24 h urine (UFC), basal and post-dexamethasone beta-endorphin values. Major depressed patients with melancholia/psychotic features exhibited a significantly lower mitogen-induced blast transformation as compared to minor and simple major depressed patients. The lymphocyte responses to the three mitogens were significantly inversely related to baseline cortisol values and postdexamethasone beta-endorphin values. The proliferative capacity of lymphocytes to stimulation with PHA and PWM was significantly and positively related to UFC excretion. Up to 45 % of the variance in the immune responses to the mitogens was explained by the baseline cortisol, postdexamethasone beta-endorphin and UFC values.|
|Notes: ||DR WILLEMS INST,DIEPENBEEK,BELGIUM.MAES, M, PSYCHIAT CTR WEYBURN,ABDIJSTR 2,B-3751 MUNSTERBILZEN,BELGIUM.|
|ISI #: ||A1991FR87300006|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.