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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3926

Title: A further exploration of the relationships between immune parameters and the hpa-axis activity in depressed-patients
Authors: Maes, Michael
BOSMANS, E
SUY, E
MINNER, B
RAUS, Jef
Issue Date: 1991
Publisher: CAMBRIDGE UNIV PRESS
Citation: PSYCHOLOGICAL MEDICINE, 21(2). p. 313-320
Abstract: In order to investigate the relationship between the immune apparatus and the hypothalamic-pituitary-adrenal (HPA)-axis activity in depressed patients, we measured in vitro lymphocyte responses to the mitogens Phytohaemagglutinin (PHA), Pokeweed (PWM) and Concanavalin A (Con A) and 8 a.m. baseline cortisol values in plasma, free cortisol excretion in 24 h urine (UFC), basal and post-dexamethasone beta-endorphin values. Major depressed patients with melancholia/psychotic features exhibited a significantly lower mitogen-induced blast transformation as compared to minor and simple major depressed patients. The lymphocyte responses to the three mitogens were significantly inversely related to baseline cortisol values and postdexamethasone beta-endorphin values. The proliferative capacity of lymphocytes to stimulation with PHA and PWM was significantly and positively related to UFC excretion. Up to 45 % of the variance in the immune responses to the mitogens was explained by the baseline cortisol, postdexamethasone beta-endorphin and UFC values.
Notes: DR WILLEMS INST,DIEPENBEEK,BELGIUM.MAES, M, PSYCHIAT CTR WEYBURN,ABDIJSTR 2,B-3751 MUNSTERBILZEN,BELGIUM.
URI: http://hdl.handle.net/1942/3926
ISI #: A1991FR87300006
ISSN: 0033-2917
Type: Journal Contribution
Appears in Collections: Research publications

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