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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3828

Title: ANTIPHOSPHOLIPID, ANTINUCLEAR, EPSTEIN-BARR AND CYTOMEGALOVIRUS ANTIBODIES, AND SOLUBLE INTERLEUKIN-2 RECEPTORS IN DEPRESSIVE PATIENTS
Authors: Maes, Michael
BOSMANS, E
SUY, E
VANDERVORST, Carine
DEJONCKHEERE, C
RAUS, Jef
Issue Date: 1991
Publisher: ELSEVIER SCIENCE BV
Citation: JOURNAL OF AFFECTIVE DISORDERS, 21(2). p. 133-140
Abstract: To determine whether depression might be associated with serologic indices of autoimmune processes or active virus infections, we measured the following parameters in healthy controls, minor, simple major and melancholic patients: antiphospholipid (anticardiolipin, antiphosphatidylserine), antinuclear, and Epstein-Barr (EBV) and cytomegalovirus (CMV) antibodies. In addition, the soluble interleukin-2 receptor (sIL-2R) circulating levels in serum were measured and used as a marker of T cell activation. The anticardiolipin antibody titers were higher in melancholics than in healthy controls and minor depressives. Antinuclear antibodies were present significantly more frequently in depressed patients than in normal volunteers. The anticardiolipin and antinuclear antibody titers were significantly and positively intercorrelated. Depression is characterized by increased serum circulating levels of sIL-2Rs compared to the healthy state. Antinuclear-positive subjects exhibited significantly higher sIL-2Rs than those without detectable antinuclear titers. There was a positive correlation between anticardiolipin activity and sIL-2Rs. We found no evidence that depression is linked to EBV or CMV infection.
Notes: EUROGENET,TESSENDERLOO,BELGIUM. UNIV DIEPENBEEK,DR WILLEMS INST,DIEPENBEEK,BELGIUM.MAES, M, PSYCHIAT CTR ST JOSEF,ABDIJSTRAAT 2,B-3751 MUNSTERBILZEN,BELGIUM.
URI: http://hdl.handle.net/1942/3828
DOI: 10.1016/0165-0327(91)90060-6
ISI #: A1991FA69700009
ISSN: 0165-0327
Type: Journal Contribution
Appears in Collections: Research publications

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