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|Title: ||HPA-AXIS HORMONES AND PROLACTIN RESPONSES TO DEXTRO-FENFLURAMINE IN DEPRESSED-PATIENTS AND HEALTHY CONTROLS|
|Authors: ||Maes, Michael|
|Issue Date: ||1991|
|Publisher: ||PERGAMON-ELSEVIER SCIENCE LTD|
|Citation: ||PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 15(6). p. 781-790|
|Abstract: ||1. Like other authors we have established disturbances in central serotonergic neurotransmission in severely depressed patients by implementing hypothalamic pituitary adrenal (HPA)-axis hormones and prolactin responses to serotonin agonists or precursors. 2. Challenge probes with D,L fenfluramine have yielded controversial results. This substance, however, is not as serotonin-selective as previously believed. 3. Dextro(D)-fenfluramine, the dextrorotatory isomer of fenfluramine, constitutes a specific and potent serotonergic agonist. 4. In the present study the authors determined the following in healthy volunteers, and in depressed inpatients: the adrenocorticotropic hormone (ACTH), beta-endorphin, prolactin and cortisol responses to D-fenfluramine administration (45 mg orally), total L-tryptophan and the 8 a.m. postdexamethasone cortisol values. 5. We found no significant differences in any of the post-D-fenfluramine hormone levels across healthy controls, minor, simple major and melancholic depressives. There were no significant correlations between L-tryptophan or postdexamethasone cortisol on the one hand, and any of the post-D-fenfluramine hormone values on the other.|
|Notes: ||PSYCHIAT CTR ST JOSEF,MUNSTERBILZEN,BELGIUM. UNIV DIEPENBEEK,DR WILLEMS INST,DIEPENBEEK,BELGIUM.|
|ISI #: ||A1991GN29700007|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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