www.uhasselt.be
DSpace

Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3821

Title: IMMUNE DISTURBANCES DURING MAJOR DEPRESSION - UP-REGULATED EXPRESSION OF INTERLEUKIN-2 RECEPTORS
Authors: Maes, Michael
BOSMANS, E
SUY, E
DEJONCKHEERE, C
VANDERVORST, Carine
RAUS, Jef
Issue Date: 1991
Publisher: KARGER
Citation: NEUROPSYCHOBIOLOGY, 24(3). p. 115-120
Abstract: We determined the following immune parameters in drug-free, major depressed patients and in age- and sex-matched healthy controls: the number and percentage of interleukin-2 receptor (IL-2R) bearing cells (CD25+, anti-TAC), serum circulating levels of soluble (s)IL-2Rs, the pre- and postdexamethasone phytohemagglutinin (PHA)-induced accumulation of sIL-2Rs in culture supernatant, and the number of T helper (CD4+) and T suppressor (CD8+) cells. In comparison with normal volunteers, patients with major depression had a higher number and percentage of CD25+ cells, higher concentrations of serum circulating sIL-2Rs, higher supernatant sIL-2Rs after stimulation with PHA, and a higher number of CD4+ cells. The CD4+/CD8+ ratio and the number of CD4+ cells were significantly and positively related to the number of cells expressing the CD25+ antigen. These results may indicate that depressed patients display an increased number of T cells in an early phase of activation.
Notes: DR WILLEMS INST,DIEPENBEEK,BELGIUM. EUROGENET,TESSENDERLOO,BELGIUM.MAES, M, PSYCHIAT CTR ST JOSEF,ABDIJST 2,B-3751 MUNSTERBILZEN,BELGIUM.
URI: http://hdl.handle.net/1942/3821
ISI #: A1991HG89000003
ISSN: 0302-282X
Type: Journal Contribution
Appears in Collections: Research publications

Files in This Item:

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.