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|Title: ||MHC-RESTRICTED DEPLETION OF HUMAN MYELIN BASIC-PROTEIN REACTIVE T-CELLS BY T-CELL VACCINATION|
|Authors: ||Zhang, JK|
|Issue Date: ||1993|
|Publisher: ||AMER ASSOC ADVANCEMENT SCIENCE|
|Citation: ||SCIENCE, 261(5127). p. 1451-1454|
|Abstract: ||Activated autoreactive T cells are potentially pathogenic and regulated by clonotypic networks. Experimental autoimmune diseases can be treated by inoculation with autoreactive T cells (T cell vaccination). In the present study, patients with multiple sclerosis were inoculated with irradiated myelin basic protein (MBP)-reactive T cells. T cell responses to the inoculates were induced to deplete circulating MBP-reactive T cells in the recipients. Regulatory T cell lines isolated from the recipients inhibited T cells used for vaccination. The cytotoxicity of the CDB+ T cell lines was restricted by major histocompatibility antigens. Thus, clonotypic interactions regulating autoreactive T cells in humans can be induced by T cell vaccination.|
|Notes: ||DR L WILLEMS INST,DEPT IMMUNOL,B-3590 DIEPENBEEK,BELGIUM. BRIGHAM & WOMENS HOSP,DEPT MED,DIV NEUROL,CTR NEUROL DIS,BOSTON,MA 02115. LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM. HARVARD UNIV,SCH MED,BOSTON,MA 02115.ZHANG, JW, DR L WILLEMS INST,MULTIPLE SCLEROSIS RES UNIT,B-3590 DIEPENBEEK,BELGIUM.|
|ISI #: ||A1993LW54900034|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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