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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3813

Title: MHC-RESTRICTED DEPLETION OF HUMAN MYELIN BASIC-PROTEIN REACTIVE T-CELLS BY T-CELL VACCINATION
Authors: Zhang, JK
MEDAER, Rob
STINISSEN, Piet
HAFLER, D
RAUS, Jef
Issue Date: 1993
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
Citation: SCIENCE, 261(5127). p. 1451-1454
Abstract: Activated autoreactive T cells are potentially pathogenic and regulated by clonotypic networks. Experimental autoimmune diseases can be treated by inoculation with autoreactive T cells (T cell vaccination). In the present study, patients with multiple sclerosis were inoculated with irradiated myelin basic protein (MBP)-reactive T cells. T cell responses to the inoculates were induced to deplete circulating MBP-reactive T cells in the recipients. Regulatory T cell lines isolated from the recipients inhibited T cells used for vaccination. The cytotoxicity of the CDB+ T cell lines was restricted by major histocompatibility antigens. Thus, clonotypic interactions regulating autoreactive T cells in humans can be induced by T cell vaccination.
Notes: DR L WILLEMS INST,DEPT IMMUNOL,B-3590 DIEPENBEEK,BELGIUM. BRIGHAM & WOMENS HOSP,DEPT MED,DIV NEUROL,CTR NEUROL DIS,BOSTON,MA 02115. LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM. HARVARD UNIV,SCH MED,BOSTON,MA 02115.ZHANG, JW, DR L WILLEMS INST,MULTIPLE SCLEROSIS RES UNIT,B-3590 DIEPENBEEK,BELGIUM.
URI: http://hdl.handle.net/1942/3813
ISI #: A1993LW54900034
ISSN: 0036-8075
Type: Journal Contribution
Appears in Collections: Research publications

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