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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3800

Title: LOCALIZED BRAIN PROTON NMR-SPECTROSCOPY IN YOUNG-ADULT PHENYLKETONURIA PATIENTS
Authors: Johannik, K.
Vanhecke, P.
Francois, Baudouin
Marchal, G.
Smet, M.H.
Jaeken, Jacky
Breysem, L.
Wilms, G.
Baert, A.L.
Issue Date: 1994
Publisher: WILLIAMS & WILKINS
Citation: MAGNETIC RESONANCE IN MEDICINE, 31(1). p. 53-57
Abstract: Localized proton magnetic resonance spectroscopy with short echo time (TE= 20 ms) was used to investigate biochemical changes in the cerebral white matter of 20 young adult patients (median 19 years) with phenylketonuria (PKU). Results were compared with those of a group of 12 age-matched healthy volunteers (median 25 years). Concentrations of N-acetyl-aspartate (NAA) and choline (Cho) relative to creatine (Cr) were unchanged. However, concentrations of inositol (Ins) relative to creatine were found to be significantly lower (P < 0.001) in the PKU patients (0.30 +/- 0.09 versus 0.57 +/- 0.17). Individual inositol concentrations did not correlate with age, diet, serum phenylalanine (Phe) levels or extent of pathological regions in the T-2-weighted images. The lack of correlation with individual data suggests that the decreased inositol concentration could be related to a metabolic deficiency during fetal development. No signal from the phenyl ring protons of phenylalanine was detected in the PKU patients (phenylalanine serum concentration less than or equal to 1.27 mM), which suggests that concentration of phenylalanine may be lower in brain than in serum.
Notes: KATHOLIEKE UNIV LEUVEN HOSP,DEPT RADIOL,B-3000 LOUVAIN,BELGIUM. KATHOLIEKE UNIV LEUVEN HOSP,DEPT PEDIAT,B-3000 LOUVAIN,BELGIUM. DR L WILLEMS INST,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CTR,B-3590 DIEPENBEEK,BELGIUM.
URI: http://hdl.handle.net/1942/3800
ISI #: A1994MP54200007
ISSN: 0740-3194
Type: Journal Contribution
Appears in Collections: Research publications

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