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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3774

Title: DECREASED EXPRESSION OF THE MEMORY MARKER CD26 ON BOTH CD4+ AND CD8+ T-LYMPHOCYTES OF HIV-INFECTED SUBJECTS
Authors: VANHAM, G
KESTENS, L
DEMEESTER, I
VINGERHOETS, J
PENNE, G
VANHOOF, G
SCHARPE, S
HEYLIGEN, Harie
BOSMANS, E
GIGASE, P
CEUPPENS, JL
Issue Date: 1993
Publisher: LIPPINCOTT-RAVEN PUBL
Citation: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 6(7). p. 749-757
Abstract: Using a novel anti-CD26 (or anti-dipeptidyl peptidase IV) monoclonal antibody, we showed that the absolute numbers and the proportions of T4 and T8 cells expressing CD26 were significantly lower in HIV-infected persons than in controls. The absolute number of CD26+ T4 cells decreased according to disease progression, whereas the number of CD26+ T8 cells was low throughout all clinical stages. These trends were similar in CD26 dim and bright positive T-cell subsets. In both controls and HIV-positive subjects, the CD26 bright positive T cells were restricted to the CD45RO+ subset and preferentially co-expressed CD25 but largely lacked HLA-DR and CD38. Recall antigen-responsive cells from seronegative individuals were shown to co-express CD26 and CD45RO. The deficient CD26 expression on T8 cells from HIV-infected subjects could be normally upregulated after in vitro stimulation. In contrast to decreased T-cell-bound CD26, the enzymatic activity of plasma CD26/dipeptidyl peptidase IV was unchanged in HIV-infected patients compared with controls. We conclude that HIV infection leads to a deficient in vivo co-expression of CD26 bright and CD45RO on T cells. We speculate that this deficiency might play a part in the decrease of immunological memory during HIV infection.
Notes: UNIV INSTELLING ANTWERP,DEPT CLIN BIOCHEM,B-2610 WILRIJK,BELGIUM. DR L WILLEMS INST,DIEPENBEEK,BELGIUM. EUROGENET,TESSENDERLO,BELGIUM. CATHOLIC UNIV LEUVEN,FAC MED,DIV CLIN IMMUNOL,B-3000 LOUVAIN,BELGIUM.VANHAM, G, INST TROP MED,PATHOL & IMMUNOL LAB,NATL STR 155,B-2000 ANTWERP 1,BELGIUM.
URI: http://hdl.handle.net/1942/3774
ISI #: A1993LH85200001
ISSN: 1077-9450
Type: Journal Contribution
Appears in Collections: Research publications

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