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|Title: ||DECREASED EXPRESSION OF THE MEMORY MARKER CD26 ON BOTH CD4+ AND CD8+ T-LYMPHOCYTES OF HIV-INFECTED SUBJECTS|
|Authors: ||VANHAM, G|
|Issue Date: ||1993|
|Publisher: ||LIPPINCOTT-RAVEN PUBL|
|Citation: ||JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 6(7). p. 749-757|
|Abstract: ||Using a novel anti-CD26 (or anti-dipeptidyl peptidase IV) monoclonal antibody, we showed that the absolute numbers and the proportions of T4 and T8 cells expressing CD26 were significantly lower in HIV-infected persons than in controls. The absolute number of CD26+ T4 cells decreased according to disease progression, whereas the number of CD26+ T8 cells was low throughout all clinical stages. These trends were similar in CD26 dim and bright positive T-cell subsets. In both controls and HIV-positive subjects, the CD26 bright positive T cells were restricted to the CD45RO+ subset and preferentially co-expressed CD25 but largely lacked HLA-DR and CD38. Recall antigen-responsive cells from seronegative individuals were shown to co-express CD26 and CD45RO. The deficient CD26 expression on T8 cells from HIV-infected subjects could be normally upregulated after in vitro stimulation. In contrast to decreased T-cell-bound CD26, the enzymatic activity of plasma CD26/dipeptidyl peptidase IV was unchanged in HIV-infected patients compared with controls. We conclude that HIV infection leads to a deficient in vivo co-expression of CD26 bright and CD45RO on T cells. We speculate that this deficiency might play a part in the decrease of immunological memory during HIV infection.|
|Notes: ||UNIV INSTELLING ANTWERP,DEPT CLIN BIOCHEM,B-2610 WILRIJK,BELGIUM. DR L WILLEMS INST,DIEPENBEEK,BELGIUM. EUROGENET,TESSENDERLO,BELGIUM. CATHOLIC UNIV LEUVEN,FAC MED,DIV CLIN IMMUNOL,B-3000 LOUVAIN,BELGIUM.VANHAM, G, INST TROP MED,PATHOL & IMMUNOL LAB,NATL STR 155,B-2000 ANTWERP 1,BELGIUM.|
|ISI #: ||A1993LH85200001|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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